Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_APOE33_old_HC_youngAD Exclusive	TIER1_GS	4.34e-01	7.89e-01	7.18e-01	3.70e-01
TIER1_GS Exclusive	Sigma_EA_APOE33_old_HC_youngAD	4.78e-02	9.32e-01	3.45e-01	5.03e-01
Sigma_EA_APOE33_old_HC_youngAD Exclusive	TIER1_GS Exclusive	4.12e-01	8.86e-01	7.26e-01	5.77e-01
TIER1_GS Exclusive	Sigma_EA_APOE33_old_HC_youngAD Exclusive	3.27e-02	9.26e-01	2.82e-01	6.57e-01
Sigma_EA_APOE33_old_HC_youngAD Exclusive	Overlap	8.32e-01	7.33e-01	5.74e-01	7.13e-01
TIER1_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	3.71e-05	1.26e-04	3.44e-06	9.18e-06



Evaluating how well Sigma_EA_APOE33_old_HC_youngAD genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_APOE33_old_HC_youngAD Exclusive	TIER1_GS	0.58	-0.94	-0.42	-0.26	1.45
TIER1_GS Exclusive	Sigma_EA_APOE33_old_HC_youngAD	0.52	-0.14	0.05	0.28	0.81
Sigma_EA_APOE33_old_HC_youngAD Exclusive	TIER1_GS Exclusive	0.58	-0.72	-0.34	-0.46	1.27
TIER1_GS Exclusive	Sigma_EA_APOE33_old_HC_youngAD Exclusive	0.52	-0.39	-0.17	-0.03	0.72
Sigma_EA_APOE33_old_HC_youngAD Exclusive	Overlap	0.65	-0.23	0.18	0.64	0.57
TIER1_GS Exclusive	Overlap	1.00	2.09	1.86	1.91	1.75
Overlap	Exclusives	0.59	2.19	3.80	3.32	4.32

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_APOE33_old_HC_youngAD Exclusive	TIER1_GS	0.01	4.27	3.93	3.46	3.26
TIER1_GS Exclusive	Sigma_EA_APOE33_old_HC_youngAD	0.01	1.29	1.51	1.45	1.09
Sigma_EA_APOE33_old_HC_youngAD Exclusive	TIER1_GS Exclusive	0.01	3.64	5.09	4.85	0.92
TIER1_GS Exclusive	Sigma_EA_APOE33_old_HC_youngAD Exclusive	0.01	0.09	-0.06	0.21	0.88
Sigma_EA_APOE33_old_HC_youngAD Exclusive	Overlap	0.00	-0.41	-0.32	0.01	-0.18
TIER1_GS Exclusive	Overlap	0.06	58.61	60.75	162.44	459.74
Overlap	Exclusives	0.03	10.57	23.09	15.55	19.37

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_APOE33_old_HC_youngAD Exclusive	147	144	AC013489.1;AC093155.3;RFPL2
TIER1_GS Exclusive	30	29	MS4A
Overlap	1	1