Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_stats_related_clean_AD_selected_2_APOE34AD_APOE3HC	tier2_gs	1.16e-01	1.45e-02	8.93e-03	3.25e-05
tier2_gs	Sigma_EUR_stats_related_clean_AD_selected_2_APOE34AD_APOE3HC	3.34e-01	1.26e-01	2.32e-03	4.85e-02



Evaluating how well Sigma_EUR_stats_related_clean_AD_selected_2_APOE34AD_APOE3HC genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_stats_related_clean_AD_selected_2_APOE34AD_APOE3HC	tier2_gs	0.72	2.84	3.94	3.50	4.72
tier2_gs	Sigma_EUR_stats_related_clean_AD_selected_2_APOE34AD_APOE3HC	0.57	2.34	2.19	1.98	2.51

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_stats_related_clean_AD_selected_2_APOE34AD_APOE3HC	tier2_gs	0.01	6.05	11.19	7.70	2.32
tier2_gs	Sigma_EUR_stats_related_clean_AD_selected_2_APOE34AD_APOE3HC	0.02	26.99	18.79	24.25	33.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_stats_related_clean_AD_selected_2_APOE34AD_APOE3HC	97	96	AC093155.3
tier2_gs	46	43	TNSF13;TNSF12;IGH