Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33 Exclusive	TIER1_GS	4.18e-01	2.16e-01	4.23e-01	1.58e-01
TIER1_GS Exclusive	Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33	1.23e-01	9.19e-01	5.49e-01	3.72e-01
Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33 Exclusive	TIER1_GS Exclusive	5.49e-01	2.23e-01	4.01e-01	2.13e-01
TIER1_GS Exclusive	Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33 Exclusive	1.39e-01	8.30e-01	5.99e-01	2.97e-01
Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33 Exclusive	Overlap	1.58e-01	3.56e-01	4.16e-01	5.74e-01
TIER1_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	7.39e-06	1.34e-05	3.94e-07	1.30e-06



Evaluating how well Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33 Exclusive	TIER1_GS	0.56	-0.21	-1.08	-0.34	1.07
TIER1_GS Exclusive	Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33	0.53	-0.54	-0.06	-0.22	0.67
Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33 Exclusive	TIER1_GS Exclusive	0.57	-0.11	-0.86	-0.36	1.20
TIER1_GS Exclusive	Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33 Exclusive	0.52	-0.42	-0.32	-0.35	0.82
Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33 Exclusive	Overlap	0.30	-1.42	-1.28	-0.94	-0.84
TIER1_GS Exclusive	Overlap	1.00	1.70	1.92	2.37	1.87
Overlap	Exclusives	0.65	2.09	4.00	2.46	4.46

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33 Exclusive	TIER1_GS	0.00	-0.47	-1.28	-0.65	-0.17
TIER1_GS Exclusive	Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33	0.00	1.50	1.40	1.04	1.72
Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33 Exclusive	TIER1_GS Exclusive	0.00	-0.47	-1.21	-0.49	-0.14
TIER1_GS Exclusive	Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33 Exclusive	0.00	-0.62	-0.42	-0.43	-0.07
Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33 Exclusive	Overlap	0.00	-0.28	-0.36	-0.29	-0.33
TIER1_GS Exclusive	Overlap	0.06	34.06	71.50	328.91	146.08
Overlap	Exclusives	0.03	23.93	37.51	17.77	44.98

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33 Exclusive	63	63	
TIER1_GS Exclusive	30	29	MS4A
Overlap	1	1