Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33	tier2_gs	5.96e-01	3.45e-01	3.37e-01	1.54e-02
tier2_gs	Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33	9.62e-01	7.85e-01	8.55e-02	3.44e-01



Evaluating how well Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33	tier2_gs	0.64	1.48	1.89	1.32	3.06
tier2_gs	Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33	0.53	0.33	0.51	0.18	1.05

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33	tier2_gs	0.00	0.77	1.05	0.76	1.63
tier2_gs	Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33	0.02	48.45	33.40	5.42	29.48

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_stats_related_clean_AD_ADC_AD_APOE33_HC_APOE33	64	64	
tier2_gs	46	43	TNSF13;IGH;TNSF12