Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_WES_AF_01_1 Exclusive	tier1_31	2.51e-10	1.26e-10	8.96e-12	4.63e-12
tier1_31 Exclusive	Sigma_EA_WES_AF_01_1	6.61e-02	8.18e-02	1.31e-02	1.01e-02
Sigma_EA_WES_AF_01_1 Exclusive	tier1_31 Exclusive	1.75e-10	3.91e-10	5.00e-11	2.10e-10
tier1_31 Exclusive	Sigma_EA_WES_AF_01_1 Exclusive	1.21e-01	8.98e-02	3.27e-02	1.90e-02
Sigma_EA_WES_AF_01_1 Exclusive	Overlap	4.89e-02	9.85e-05	3.20e-02	3.55e-03
tier1_31 Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	1.54e-05	2.96e-08	5.01e-34	4.03e-11



Evaluating how well Sigma_EA_WES_AF_01_1 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_01_1 Exclusive	tier1_31	0.87	5.48	7.47	4.32	6.91
tier1_31 Exclusive	Sigma_EA_WES_AF_01_1	0.58	2.44	2.87	2.59	3.11
Sigma_EA_WES_AF_01_1 Exclusive	tier1_31 Exclusive	0.86	4.35	6.90	4.11	6.46
tier1_31 Exclusive	Sigma_EA_WES_AF_01_1 Exclusive	0.58	2.49	2.92	2.64	2.80
Sigma_EA_WES_AF_01_1 Exclusive	Overlap	0.98	1.29	2.50	1.48	2.63
tier1_31 Exclusive	Overlap	1.00	1.67	2.27	2.14	2.54
Overlap	Exclusives	0.67	8.18	8.24	3.83	6.66

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_01_1 Exclusive	tier1_31	0.06	111.19	145.09	86.49	144.05
tier1_31 Exclusive	Sigma_EA_WES_AF_01_1	0.03	20.02	44.69	15.59	45.74
Sigma_EA_WES_AF_01_1 Exclusive	tier1_31 Exclusive	0.05	116.08	140.04	59.54	154.46
tier1_31 Exclusive	Sigma_EA_WES_AF_01_1 Exclusive	0.03	44.24	49.59	35.45	35.39
Sigma_EA_WES_AF_01_1 Exclusive	Overlap	0.01	7.19	199.32	12.30	38.75
tier1_31 Exclusive	Overlap	0.03	51.69	245.31	84.68	101.07
Overlap	Exclusives	0.05	113.10	60.58	30.52	56.96

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_WES_AF_01_1 Exclusive	106	104	RFPL2;PRAMEF11
tier1_31 Exclusive	29	28	MS4A
Overlap	2	2