Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_WES_AF_0_01 Exclusive	tier1_31	5.32e-01	5.03e-01	8.50e-02	1.00e-02
tier1_31 Exclusive	Sigma_EA_WES_AF_0_01	6.97e-02	6.40e-01	2.28e-01	1.37e-01
Sigma_EA_WES_AF_0_01 Exclusive	tier1_31 Exclusive	1.96e-01	3.40e-01	5.14e-02	1.93e-03
tier1_31 Exclusive	Sigma_EA_WES_AF_0_01 Exclusive	2.13e-02	8.88e-01	4.34e-01	2.91e-01
Sigma_EA_WES_AF_0_01 Exclusive	Overlap	6.58e-01	5.03e-01	8.75e-01	7.04e-01
tier1_31 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	2.28e-04	2.29e-04	5.96e-05	6.90e-05



Evaluating how well Sigma_EA_WES_AF_0_01 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_0_01 Exclusive	tier1_31	0.62	0.24	0.35	0.48	2.50
tier1_31 Exclusive	Sigma_EA_WES_AF_0_01	0.55	-0.39	0.62	0.42	1.67
Sigma_EA_WES_AF_0_01 Exclusive	tier1_31 Exclusive	0.63	0.47	0.54	0.50	2.65
tier1_31 Exclusive	Sigma_EA_WES_AF_0_01 Exclusive	0.54	-1.11	-0.08	-0.07	0.87
Sigma_EA_WES_AF_0_01 Exclusive	Overlap	0.49	-0.59	-0.89	-0.45	0.02
tier1_31 Exclusive	Overlap	1.00	3.10	2.76	3.23	3.43
Overlap	Exclusives	0.65	2.04	4.51	3.04	5.07

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_0_01 Exclusive	tier1_31	0.00	-0.32	-0.72	-0.17	0.68
tier1_31 Exclusive	Sigma_EA_WES_AF_0_01	0.01	14.16	16.40	14.23	13.97
Sigma_EA_WES_AF_0_01 Exclusive	tier1_31 Exclusive	0.00	-0.30	-0.77	-0.18	0.44
tier1_31 Exclusive	Sigma_EA_WES_AF_0_01 Exclusive	0.00	-0.15	0.20	0.33	0.28
Sigma_EA_WES_AF_0_01 Exclusive	Overlap	0.00	-0.37	-0.64	-0.31	-0.25
tier1_31 Exclusive	Overlap	0.21	975.18	247.25	283.77	985.84
Overlap	Exclusives	0.08	63.23	122.16	88.08	119.30

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_WES_AF_0_01 Exclusive	75	74	AC131097.2
tier1_31 Exclusive	28	27	MS4A
Overlap	3	3