Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigmaEA_WESR2_122 Exclusive	tier2_gs	9.11e-03	3.28e-03	4.39e-04	1.39e-05
tier2_gs Exclusive	sigmaEA_WESR2_122	1.55e-01	7.02e-02	3.20e-04	2.57e-03
sigmaEA_WESR2_122 Exclusive	tier2_gs Exclusive	1.48e-02	8.77e-03	9.52e-04	4.11e-05
tier2_gs Exclusive	sigmaEA_WESR2_122 Exclusive	1.67e-01	7.28e-02	4.04e-04	4.04e-03
sigmaEA_WESR2_122 Exclusive	Overlap	3.96e-02	5.94e-02	1.98e-02	1.58e-01
tier2_gs Exclusive	Overlap	1.58e-01	4.95e-01	2.18e-01	2.18e-01
Overlap	Exclusives	4.08e-03	1.96e-02	1.09e-08	2.33e-06



Evaluating how well sigmaEA_WESR2_122 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigmaEA_WESR2_122 Exclusive	tier2_gs	0.68	1.92	2.75	2.15	4.92
tier2_gs Exclusive	sigmaEA_WESR2_122	0.59	2.75	2.91	2.36	3.70
sigmaEA_WESR2_122 Exclusive	tier2_gs Exclusive	0.68	2.38	2.58	2.12	3.74
tier2_gs Exclusive	sigmaEA_WESR2_122 Exclusive	0.59	2.46	2.81	2.88	3.80
sigmaEA_WESR2_122 Exclusive	Overlap	0.96	1.46	1.65	1.94	1.64
tier2_gs Exclusive	Overlap	0.84	1.58	1.00	1.19	1.50
Overlap	Exclusives	0.60	1.97	2.55	2.04	4.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigmaEA_WESR2_122 Exclusive	tier2_gs	0.01	3.94	10.48	9.77	13.23
tier2_gs Exclusive	sigmaEA_WESR2_122	0.01	8.15	8.08	4.57	5.95
sigmaEA_WESR2_122 Exclusive	tier2_gs Exclusive	0.01	5.42	11.06	6.93	13.30
tier2_gs Exclusive	sigmaEA_WESR2_122 Exclusive	0.01	6.35	8.61	7.81	4.43
sigmaEA_WESR2_122 Exclusive	Overlap	0.00	2.86	1.42	6.50	2.53
tier2_gs Exclusive	Overlap	0.00	0.48	-0.07	0.55	0.40
Overlap	Exclusives	0.01	2.22	3.41	2.27	6.27

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigmaEA_WESR2_122 Exclusive	121	120	RFPL2
tier2_gs Exclusive	45	42	TNSF12;TNSF13;IGH
Overlap	1	1