Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_WES_AF_01_1_108 Exclusive	tier2_gs	5.25e-02	1.11e-02	7.27e-03	1.00e-03
tier2_gs Exclusive	Sigma_EA_WES_AF_01_1_108	1.99e-01	3.81e-01	2.90e-03	6.88e-02
Sigma_EA_WES_AF_01_1_108 Exclusive	tier2_gs Exclusive	4.15e-02	6.68e-03	6.47e-03	7.80e-04
tier2_gs Exclusive	Sigma_EA_WES_AF_01_1_108 Exclusive	2.27e-01	2.86e-01	3.76e-03	1.13e-01
Sigma_EA_WES_AF_01_1_108 Exclusive	Overlap	8.51e-01	9.70e-01	9.50e-01	5.74e-01
tier2_gs Exclusive	Overlap	3.17e-01	6.34e-01	2.38e-01	3.96e-01
Overlap	Exclusives	8.37e-02	1.24e-01	2.93e-07	2.86e-04



Evaluating how well Sigma_EA_WES_AF_01_1_108 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_01_1_108 Exclusive	tier2_gs	0.66	1.09	1.93	1.69	3.32
tier2_gs Exclusive	Sigma_EA_WES_AF_01_1_108	0.57	2.18	1.96	1.91	2.74
Sigma_EA_WES_AF_01_1_108 Exclusive	tier2_gs Exclusive	0.66	1.13	2.42	1.69	3.84
tier2_gs Exclusive	Sigma_EA_WES_AF_01_1_108 Exclusive	0.57	2.20	2.00	2.05	2.33
Sigma_EA_WES_AF_01_1_108 Exclusive	Overlap	0.63	0.11	0.09	0.05	0.68
tier2_gs Exclusive	Overlap	0.84	1.22	0.75	1.20	1.07
Overlap	Exclusives	0.58	1.33	1.74	1.24	3.30

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_01_1_108 Exclusive	tier2_gs	0.01	4.33	7.16	5.96	6.19
tier2_gs Exclusive	Sigma_EA_WES_AF_01_1_108	0.01	4.55	2.46	3.70	2.33
Sigma_EA_WES_AF_01_1_108 Exclusive	tier2_gs Exclusive	0.01	3.28	7.85	6.26	7.05
tier2_gs Exclusive	Sigma_EA_WES_AF_01_1_108 Exclusive	0.01	4.26	3.27	3.35	4.94
Sigma_EA_WES_AF_01_1_108 Exclusive	Overlap	0.00	-0.25	-0.40	-0.37	-0.15
tier2_gs Exclusive	Overlap	0.00	0.27	-0.21	0.03	-0.01
Overlap	Exclusives	0.01	0.65	2.00	0.88	3.39

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_WES_AF_01_1_108 Exclusive	107	105	PRAMEF11;RFPL2
tier2_gs Exclusive	45	42	TNSF12;TNSF13;IGH
Overlap	1	1