Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_WES_AF_0_01	tier2_gs	4.22e-02	1.44e-01	4.37e-03	7.46e-04
tier2_gs	Sigma_EA_WES_AF_0_01	7.50e-01	9.84e-02	7.09e-03	3.43e-02



Evaluating how well Sigma_EA_WES_AF_0_01 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_0_01	tier2_gs	0.67	2.16	2.46	2.47	3.76
tier2_gs	Sigma_EA_WES_AF_0_01	0.58	1.38	1.71	1.56	2.28

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_0_01	tier2_gs	0.01	5.52	6.27	5.62	8.84
tier2_gs	Sigma_EA_WES_AF_0_01	0.02	32.99	30.11	29.70	19.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_WES_AF_0_01	78	77	AC131097.2
tier2_gs	46	43	IGH;TNSF13;TNSF12