Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) Sigma_EA_WES_AF_0_01 tier2_gs 4.22e-02 1.44e-01 4.37e-03 7.46e-04 tier2_gs Sigma_EA_WES_AF_0_01 7.50e-01 9.84e-02 7.09e-03 3.43e-02 Evaluating how well Sigma_EA_WES_AF_0_01 genes are linked to tier2_gs genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Sigma_EA_WES_AF_0_01 tier2_gs 0.67 2.16 2.46 2.47 3.76 tier2_gs Sigma_EA_WES_AF_0_01 0.58 1.38 1.71 1.56 2.28 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Sigma_EA_WES_AF_0_01 tier2_gs 0.01 5.52 6.27 5.62 8.84 tier2_gs Sigma_EA_WES_AF_0_01 0.02 32.99 30.11 29.70 19.01 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes Sigma_EA_WES_AF_0_01 78 77 AC131097.2 tier2_gs 46 43 IGH;TNSF13;TNSF12