Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	tier1_31	7.44e-09	6.78e-08	8.09e-10	1.78e-10
tier1_31 Exclusive	Sigma_EA_WES_AF_0_01_1_78_108	5.92e-02	1.46e-01	5.82e-03	1.11e-02
Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	tier1_31 Exclusive	3.59e-06	5.61e-06	3.55e-07	2.56e-07
tier1_31 Exclusive	Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	2.43e-01	3.29e-01	5.03e-02	7.68e-02
Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	Overlap	1.49e-08	7.92e-04	1.88e-09	9.59e-09
tier1_31 Exclusive	Overlap	7.45e-12	7.45e-12	7.45e-12	7.45e-12
Overlap	Exclusives	3.61e-04	9.99e-04	3.36e-17	1.36e-05



Evaluating how well Sigma_EA_WES_AF_0_01_1_78_108 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	tier1_31	0.86	4.37	6.80	5.02	6.94
tier1_31 Exclusive	Sigma_EA_WES_AF_0_01_1_78_108	0.57	2.33	2.25	2.31	3.61
Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	tier1_31 Exclusive	0.83	4.81	6.68	3.89	5.42
tier1_31 Exclusive	Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	0.56	2.09	1.75	2.04	2.36
Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	Overlap	0.99	3.28	2.95	3.51	3.77
tier1_31 Exclusive	Overlap	1.00	3.09	3.65	3.29	3.63
Overlap	Exclusives	0.61	3.77	5.65	3.20	5.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	tier1_31	0.03	44.46	64.10	52.02	67.37
tier1_31 Exclusive	Sigma_EA_WES_AF_0_01_1_78_108	0.04	20.67	45.05	30.49	41.00
Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	tier1_31 Exclusive	0.02	54.00	62.92	45.08	41.25
tier1_31 Exclusive	Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	0.02	16.36	23.36	18.59	17.67
Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	Overlap	0.02	28.38	23.44	31.65	7.63
tier1_31 Exclusive	Overlap	0.16	219.12	236.92	341.27	690.29
Overlap	Exclusives	0.08	60.24	103.33	57.27	98.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	179	176	RFPL2;AC131097.2;PRAMEF11
tier1_31 Exclusive	26	25	MS4A
Overlap	5	5