Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	tier2_gs	2.87e-02	4.14e-02	5.36e-03	2.74e-04
tier2_gs Exclusive	Sigma_EA_WES_AF_0_01_1_78_108	2.37e-01	4.22e-02	7.93e-05	4.75e-03
Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	tier2_gs Exclusive	4.30e-02	7.37e-02	1.28e-02	3.80e-04
tier2_gs Exclusive	Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	2.21e-01	7.87e-02	1.42e-04	4.33e-03
Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	Overlap	5.94e-02	2.18e-01	7.92e-02	1.98e-01
tier2_gs Exclusive	Overlap	1.39e-01	4.55e-01	1.78e-01	4.16e-01
Overlap	Exclusives	5.99e-03	8.94e-03	4.86e-12	9.75e-06



Evaluating how well Sigma_EA_WES_AF_0_01_1_78_108 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	tier2_gs	0.68	1.81	2.07	2.02	4.31
tier2_gs Exclusive	Sigma_EA_WES_AF_0_01_1_78_108	0.57	2.32	2.74	2.10	3.18
Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	tier2_gs Exclusive	0.67	1.79	2.18	1.83	3.96
tier2_gs Exclusive	Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	0.57	1.89	2.47	2.78	3.98
Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	Overlap	0.93	1.90	1.36	1.56	1.39
tier2_gs Exclusive	Overlap	0.84	1.61	0.93	1.28	1.04
Overlap	Exclusives	0.58	2.27	2.67	1.88	3.95

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	tier2_gs	0.01	2.81	15.91	8.15	19.13
tier2_gs Exclusive	Sigma_EA_WES_AF_0_01_1_78_108	0.02	6.61	8.58	8.05	9.08
Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	tier2_gs Exclusive	0.01	7.93	15.79	9.84	3.93
tier2_gs Exclusive	Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	0.02	6.70	7.65	6.74	8.23
Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	Overlap	0.00	3.65	0.03	0.69	1.69
tier2_gs Exclusive	Overlap	0.00	1.77	-0.04	0.27	-0.12
Overlap	Exclusives	0.02	2.35	3.26	2.19	5.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_WES_AF_0_01_1_78_108 Exclusive	183	180	AC131097.2;RFPL2;PRAMEF11
tier2_gs Exclusive	45	42	TNSF13;TNSF12;IGH
Overlap	1	1