Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_WES_AF_0_01_78	Ismael_14_AD	3.66e-03	6.44e-02	2.17e-03	4.03e-04
Ismael_14_AD	Sigma_EA_WES_AF_0_01_78	7.14e-03	6.73e-01	5.06e-04	9.10e-02



Evaluating how well Sigma_EA_WES_AF_0_01_78 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_0_01_78	Ismael_14_AD	0.81	2.19	2.37	1.85	3.74
Ismael_14_AD	Sigma_EA_WES_AF_0_01_78	0.56	0.57	0.73	0.82	1.75

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_0_01_78	Ismael_14_AD	0.00	6.05	6.42	4.17	1.86
Ismael_14_AD	Sigma_EA_WES_AF_0_01_78	0.01	2.95	3.24	1.00	1.48

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_WES_AF_0_01_78	78	77	AC131097.2
Ismael_14_AD	14	14