Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_WES_AF_01_1_108	Ismael_14_AD	5.53e-01	8.42e-01	3.46e-01	7.32e-02
Ismael_14_AD	Sigma_EA_WES_AF_01_1_108	1.70e-01	4.07e-01	2.34e-05	1.02e-01



Evaluating how well Sigma_EA_WES_AF_01_1_108 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_01_1_108	Ismael_14_AD	0.68	-0.14	0.03	0.07	2.50
Ismael_14_AD	Sigma_EA_WES_AF_01_1_108	0.55	1.11	1.06	0.97	1.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_01_1_108	Ismael_14_AD	0.00	0.67	2.75	1.05	0.17
Ismael_14_AD	Sigma_EA_WES_AF_01_1_108	0.01	0.56	0.91	0.80	0.46

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_WES_AF_01_1_108	108	106	PRAMEF11;RFPL2
Ismael_14_AD	14	14