Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_EA_122_genes	Ismael_14_AD	8.42e-02	1.80e-01	2.95e-02	7.27e-03
Ismael_14_AD	sigma_EA_122_genes	1.85e-02	4.01e-01	5.71e-06	5.06e-02



Evaluating how well sigma_EA_122_genes genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EA_122_genes	Ismael_14_AD	0.76	1.15	1.31	1.21	3.39
Ismael_14_AD	sigma_EA_122_genes	0.54	0.49	0.06	0.24	1.51

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EA_122_genes	Ismael_14_AD	0.00	2.14	3.14	2.79	1.88
Ismael_14_AD	sigma_EA_122_genes	0.01	1.46	1.96	0.98	2.81

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_EA_122_genes	122	121	RFPL2
Ismael_14_AD	14	14