Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_WES_AF_0_01_1_78_108	Ismael_14_AD	9.52e-02	3.89e-01	1.62e-02	3.81e-03
Ismael_14_AD	Sigma_EA_WES_AF_0_01_1_78_108	6.00e-03	2.44e-01	3.12e-08	2.09e-02



Evaluating how well Sigma_EA_WES_AF_0_01_1_78_108 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_0_01_1_78_108	Ismael_14_AD	0.76	0.91	1.27	1.59	2.74
Ismael_14_AD	Sigma_EA_WES_AF_0_01_1_78_108	0.55	1.40	1.35	1.18	2.30

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_0_01_1_78_108	Ismael_14_AD	0.01	3.42	6.03	6.70	4.36
Ismael_14_AD	Sigma_EA_WES_AF_0_01_1_78_108	0.01	1.90	2.94	1.90	2.08

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_WES_AF_0_01_1_78_108	184	181	AC131097.2;PRAMEF11;RFPL2
Ismael_14_AD	14	14