Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
union_differnt _AF_202 Exclusive	tier1_31	2.93e-08	2.06e-07	4.69e-09	6.49e-10
tier1_31 Exclusive	union_differnt _AF_202	4.59e-02	8.10e-02	3.93e-03	7.44e-03
union_differnt _AF_202 Exclusive	tier1_31 Exclusive	3.56e-05	7.78e-06	4.22e-07	1.89e-07
tier1_31 Exclusive	union_differnt _AF_202 Exclusive	1.92e-01	2.14e-01	2.89e-02	2.72e-02
union_differnt _AF_202 Exclusive	Overlap	1.77e-06	9.56e-04	6.39e-08	1.88e-09
tier1_31 Exclusive	Overlap	7.45e-12	7.45e-12	7.45e-12	7.45e-12
Overlap	Exclusives	7.60e-04	1.31e-03	1.92e-16	1.15e-06



Evaluating how well union_differnt _AF_202 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
union_differnt _AF_202 Exclusive	tier1_31	0.85	3.75	7.64	4.49	7.16
tier1_31 Exclusive	union_differnt _AF_202	0.57	2.39	2.34	2.57	2.98
union_differnt _AF_202 Exclusive	tier1_31 Exclusive	0.83	4.12	5.91	4.12	6.19
tier1_31 Exclusive	union_differnt _AF_202 Exclusive	0.56	1.85	1.68	2.03	2.66
union_differnt _AF_202 Exclusive	Overlap	0.99	4.25	3.49	3.11	4.26
tier1_31 Exclusive	Overlap	1.00	3.22	4.14	3.24	3.74
Overlap	Exclusives	0.60	3.44	4.87	3.26	5.88

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
union_differnt _AF_202 Exclusive	tier1_31	0.03	31.28	54.00	39.59	26.99
tier1_31 Exclusive	union_differnt _AF_202	0.04	25.86	36.21	20.50	33.37
union_differnt _AF_202 Exclusive	tier1_31 Exclusive	0.02	30.71	40.97	40.36	38.67
tier1_31 Exclusive	union_differnt _AF_202 Exclusive	0.02	15.65	15.93	18.29	17.94
union_differnt _AF_202 Exclusive	Overlap	0.01	16.19	31.12	26.22	30.82
tier1_31 Exclusive	Overlap	0.16	389.22	322.34	321.56	484.23
Overlap	Exclusives	0.08	42.43	88.68	51.77	91.73

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
union_differnt _AF_202 Exclusive	197	194	RFPL2;AC131097.2;PRAMEF11
tier1_31 Exclusive	26	25	MS4A
Overlap	5	5