Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
union_differnt _AF_202 Exclusive	tier2_gs	9.78e-03	1.61e-02	1.16e-03	1.20e-04
tier2_gs Exclusive	union_differnt _AF_202	2.55e-01	8.55e-02	5.09e-05	4.94e-03
union_differnt _AF_202 Exclusive	tier2_gs Exclusive	2.73e-02	5.01e-02	2.31e-03	1.52e-04
tier2_gs Exclusive	union_differnt _AF_202 Exclusive	2.47e-01	1.37e-01	1.44e-04	7.10e-03
union_differnt _AF_202 Exclusive	Overlap	7.92e-02	1.98e-01	3.96e-02	2.38e-01
tier2_gs Exclusive	Overlap	9.90e-02	4.16e-01	1.19e-01	1.98e-01
Overlap	Exclusives	7.56e-03	6.36e-03	2.42e-09	4.18e-06



Evaluating how well union_differnt _AF_202 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
union_differnt _AF_202 Exclusive	tier2_gs	0.68	1.62	2.45	2.12	4.27
tier2_gs Exclusive	union_differnt _AF_202	0.57	2.21	2.61	2.35	3.64
union_differnt _AF_202 Exclusive	tier2_gs Exclusive	0.67	1.58	1.78	1.73	3.77
tier2_gs Exclusive	union_differnt _AF_202 Exclusive	0.57	2.24	2.54	2.70	3.46
union_differnt _AF_202 Exclusive	Overlap	0.93	1.62	1.55	1.75	1.37
tier2_gs Exclusive	Overlap	0.84	1.84	1.06	1.25	1.24
Overlap	Exclusives	0.58	1.92	2.36	1.79	4.07

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
union_differnt _AF_202 Exclusive	tier2_gs	0.01	3.16	17.38	9.52	27.65
tier2_gs Exclusive	union_differnt _AF_202	0.02	8.13	7.86	7.81	10.60
union_differnt _AF_202 Exclusive	tier2_gs Exclusive	0.01	8.52	17.24	10.79	20.31
tier2_gs Exclusive	union_differnt _AF_202 Exclusive	0.02	5.67	7.77	5.30	10.90
union_differnt _AF_202 Exclusive	Overlap	0.00	1.13	0.34	3.43	0.06
tier2_gs Exclusive	Overlap	0.00	2.51	-0.04	0.29	0.20
Overlap	Exclusives	0.02	1.49	2.58	2.18	4.83

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
union_differnt _AF_202 Exclusive	201	198	RFPL2;AC131097.2;PRAMEF11
tier2_gs Exclusive	45	42	IGH;TNSF12;TNSF13
Overlap	1	1