Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
union_differnt _AF_202	Ismael_14_AD	6.63e-02	4.01e-01	1.59e-02	3.81e-03
Ismael_14_AD	union_differnt _AF_202	1.35e-03	1.67e-01	1.82e-09	1.85e-02



Evaluating how well union_differnt _AF_202 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
union_differnt _AF_202	Ismael_14_AD	0.75	0.96	0.95	0.95	3.66
Ismael_14_AD	union_differnt _AF_202	0.55	0.77	1.15	1.03	2.46

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
union_differnt _AF_202	Ismael_14_AD	0.01	3.71	7.47	4.63	10.73
Ismael_14_AD	union_differnt _AF_202	0.01	1.68	2.56	1.99	3.50

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
union_differnt _AF_202	202	199	RFPL2;AC131097.2;PRAMEF11
Ismael_14_AD	14	14