Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_WES_AF_01_1_108 Exclusive	Sigma_EA_WES_AF_0_01_78	7.45e-01	4.11e-01	4.46e-01	5.03e-02
Sigma_EA_WES_AF_0_01_78 Exclusive	Sigma_EA_WES_AF_01_1_108	2.64e-01	1.66e-01	6.22e-02	1.47e-01
Sigma_EA_WES_AF_01_1_108 Exclusive	Sigma_EA_WES_AF_0_01_78 Exclusive	7.32e-01	3.77e-01	5.34e-01	6.65e-02
Sigma_EA_WES_AF_0_01_78 Exclusive	Sigma_EA_WES_AF_01_1_108 Exclusive	3.60e-01	1.55e-01	5.52e-02	2.14e-01
Sigma_EA_WES_AF_01_1_108 Exclusive	Overlap	7.08e-01	3.69e-01	9.78e-01	2.66e-01
Sigma_EA_WES_AF_0_01_78 Exclusive	Overlap	5.37e-01	7.08e-01	6.44e-01	6.77e-01
Overlap	Exclusives	1.98e-01	6.07e-01	3.11e-20	3.66e-01



Evaluating how well Sigma_EA_WES_AF_01_1_108 genes are linked to Sigma_EA_WES_AF_0_01_78 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_01_1_108 Exclusive	Sigma_EA_WES_AF_0_01_78	0.57	0.95	1.32	0.93	2.23
Sigma_EA_WES_AF_0_01_78 Exclusive	Sigma_EA_WES_AF_01_1_108	0.54	1.07	0.82	0.63	1.67
Sigma_EA_WES_AF_01_1_108 Exclusive	Sigma_EA_WES_AF_0_01_78 Exclusive	0.57	1.06	1.34	0.59	1.71
Sigma_EA_WES_AF_0_01_78 Exclusive	Sigma_EA_WES_AF_01_1_108 Exclusive	0.54	0.85	0.89	1.04	1.56
Sigma_EA_WES_AF_01_1_108 Exclusive	Overlap	0.73	-0.60	-2.16	-0.16	1.03
Sigma_EA_WES_AF_0_01_78 Exclusive	Overlap	0.63	-1.85	-1.39	-1.10	0.62
Overlap	Exclusives	0.52	-1.15	-1.14	-0.19	0.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_01_1_108 Exclusive	Sigma_EA_WES_AF_0_01_78	0.01	2.72	7.35	1.72	8.07
Sigma_EA_WES_AF_0_01_78 Exclusive	Sigma_EA_WES_AF_01_1_108	0.01	4.98	4.01	3.86	4.35
Sigma_EA_WES_AF_01_1_108 Exclusive	Sigma_EA_WES_AF_0_01_78 Exclusive	0.01	7.19	6.95	1.61	8.48
Sigma_EA_WES_AF_0_01_78 Exclusive	Sigma_EA_WES_AF_01_1_108 Exclusive	0.01	4.02	4.66	3.48	4.46
Sigma_EA_WES_AF_01_1_108 Exclusive	Overlap	0.00	-0.45	-7.26	-0.39	-0.14
Sigma_EA_WES_AF_0_01_78 Exclusive	Overlap	0.00	-0.46	-0.45	-0.17	-0.10
Overlap	Exclusives	0.01	-2.02	-0.94	-0.48	-0.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_WES_AF_01_1_108 Exclusive	106	104	RFPL2;PRAMEF11
Sigma_EA_WES_AF_0_01_78 Exclusive	76	75	AC131097.2
Overlap	2	2