Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_EA_122_genes Exclusive	Sigma_EA_WES_AF_01_1_108	2.63e-01	2.44e-01	5.87e-03	2.01e-02
Sigma_EA_WES_AF_01_1_108 Exclusive	sigma_EA_122_genes	9.21e-02	4.81e-02	6.44e-03	2.30e-03
sigma_EA_122_genes Exclusive	Sigma_EA_WES_AF_01_1_108 Exclusive	8.61e-02	1.39e-01	3.30e-02	3.27e-02
Sigma_EA_WES_AF_01_1_108 Exclusive	sigma_EA_122_genes Exclusive	1.80e-01	7.11e-02	1.55e-02	5.57e-03
sigma_EA_122_genes Exclusive	Overlap	8.39e-01	7.35e-01	2.59e-01	3.58e-01
Sigma_EA_WES_AF_01_1_108 Exclusive	Overlap	2.18e-01	2.11e-01	5.32e-02	6.49e-02
Overlap	Exclusives	4.70e-01	7.14e-01	3.25e-01	4.75e-02



Evaluating how well sigma_EA_122_genes genes are linked to Sigma_EA_WES_AF_01_1_108 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EA_122_genes Exclusive	Sigma_EA_WES_AF_01_1_108	0.57	1.96	1.81	2.48	2.50
Sigma_EA_WES_AF_01_1_108 Exclusive	sigma_EA_122_genes	0.59	2.78	2.85	2.67	3.11
sigma_EA_122_genes Exclusive	Sigma_EA_WES_AF_01_1_108 Exclusive	0.60	2.05	1.70	1.56	2.40
Sigma_EA_WES_AF_01_1_108 Exclusive	sigma_EA_122_genes Exclusive	0.62	2.67	3.16	2.36	3.28
sigma_EA_122_genes Exclusive	Overlap	0.56	0.48	0.78	1.35	1.38
Sigma_EA_WES_AF_01_1_108 Exclusive	Overlap	0.57	1.67	1.51	1.69	1.73
Overlap	Exclusives	0.56	0.26	0.47	0.85	2.11

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EA_122_genes Exclusive	Sigma_EA_WES_AF_01_1_108	0.01	3.27	2.34	1.81	4.01
Sigma_EA_WES_AF_01_1_108 Exclusive	sigma_EA_122_genes	0.01	1.69	0.55	2.29	1.08
sigma_EA_122_genes Exclusive	Sigma_EA_WES_AF_01_1_108 Exclusive	0.00	3.11	2.11	2.63	2.84
Sigma_EA_WES_AF_01_1_108 Exclusive	sigma_EA_122_genes Exclusive	0.00	1.90	2.34	1.59	2.34
sigma_EA_122_genes Exclusive	Overlap	0.00	0.54	0.29	1.64	1.98
Sigma_EA_WES_AF_01_1_108 Exclusive	Overlap	0.00	0.81	0.06	0.03	0.24
Overlap	Exclusives	0.01	0.98	1.78	2.13	3.38

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_EA_122_genes Exclusive	60	60	
Sigma_EA_WES_AF_01_1_108 Exclusive	46	45	PRAMEF11
Overlap	62	61	RFPL2