Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_01 Exclusive	tier1_31	8.98e-01	9.52e-01	7.12e-01	6.52e-02
tier1_31 Exclusive	Result_uniqueEUR_sigma_AF_001_01	1.31e-01	8.13e-01	8.12e-02	1.84e-01
Result_uniqueEUR_sigma_AF_001_01 Exclusive	tier1_31 Exclusive	9.17e-01	9.56e-01	6.49e-01	1.16e-01
tier1_31 Exclusive	Result_uniqueEUR_sigma_AF_001_01 Exclusive	1.34e-01	9.63e-01	2.66e-01	4.46e-01
Result_uniqueEUR_sigma_AF_001_01 Exclusive	Overlap	8.62e-01	4.31e-01	9.46e-01	7.79e-01
tier1_31 Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	8.65e-04	2.09e-05	1.20e-26	6.42e-08



Evaluating how well Result_uniqueEUR_sigma_AF_001_01 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_01 Exclusive	tier1_31	0.60	-0.00	-0.10	-0.08	1.78
tier1_31 Exclusive	Result_uniqueEUR_sigma_AF_001_01	0.54	-0.08	-0.09	-0.19	1.16
Result_uniqueEUR_sigma_AF_001_01 Exclusive	tier1_31 Exclusive	0.60	0.19	0.19	0.18	1.71
tier1_31 Exclusive	Result_uniqueEUR_sigma_AF_001_01 Exclusive	0.53	-0.45	-0.55	-0.55	0.89
Result_uniqueEUR_sigma_AF_001_01 Exclusive	Overlap	0.64	-0.71	-1.38	-0.59	0.78
tier1_31 Exclusive	Overlap	1.00	2.13	2.11	2.21	2.27
Overlap	Exclusives	0.66	4.17	6.64	2.99	6.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_01 Exclusive	tier1_31	0.00	-0.22	-0.36	-0.16	0.24
tier1_31 Exclusive	Result_uniqueEUR_sigma_AF_001_01	0.01	2.34	2.90	1.35	3.35
Result_uniqueEUR_sigma_AF_001_01 Exclusive	tier1_31 Exclusive	0.00	-0.03	-0.02	0.00	0.41
tier1_31 Exclusive	Result_uniqueEUR_sigma_AF_001_01 Exclusive	0.01	0.47	0.16	0.08	0.45
Result_uniqueEUR_sigma_AF_001_01 Exclusive	Overlap	0.00	-0.40	-1.44	-0.50	-0.03
tier1_31 Exclusive	Overlap	0.05	104.53	148.74	47.94	69.62
Overlap	Exclusives	0.03	33.97	52.33	20.07	44.83

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Result_uniqueEUR_sigma_AF_001_01 Exclusive	101	100	AC245033.1
tier1_31 Exclusive	29	28	MS4A
Overlap	2	2