Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_01	tier2_gs	8.23e-01	4.99e-01	1.14e-01	1.63e-02
tier2_gs	Result_uniqueEUR_sigma_AF_001_01	3.93e-01	5.06e-01	3.98e-03	5.55e-02



Evaluating how well Result_uniqueEUR_sigma_AF_001_01 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_01	tier2_gs	0.64	0.74	1.14	1.34	3.29
tier2_gs	Result_uniqueEUR_sigma_AF_001_01	0.55	0.55	0.82	0.59	1.99

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_01	tier2_gs	0.00	1.10	1.43	2.26	0.74
tier2_gs	Result_uniqueEUR_sigma_AF_001_01	0.02	9.09	18.59	8.55	17.93

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Result_uniqueEUR_sigma_AF_001_01	103	102	AC245033.1
tier2_gs	46	43	IGH;TNSF13;TNSF12