Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_01	AD_Ismael	7.22e-02	9.26e-02	2.81e-02	1.23e-03
AD_Ismael	Result_uniqueEUR_sigma_AF_001_01	4.98e-02	3.41e-01	2.84e-05	2.08e-02



Evaluating how well Result_uniqueEUR_sigma_AF_001_01 genes are linked to AD_Ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_01	AD_Ismael	0.81	2.76	2.94	1.76	3.69
AD_Ismael	Result_uniqueEUR_sigma_AF_001_01	0.56	1.54	0.91	0.57	2.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_01	AD_Ismael	0.00	1.59	2.19	0.97	2.36
AD_Ismael	Result_uniqueEUR_sigma_AF_001_01	0.01	1.42	2.13	1.53	2.62

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Result_uniqueEUR_sigma_AF_001_01	103	102	AC245033.1
AD_Ismael	14	14