Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Result_uniqueEUR_sigma_AF_0_001 Exclusive	TIER1_GS	5.06e-01	4.89e-01	2.30e-01	5.92e-02
TIER1_GS Exclusive	Result_uniqueEUR_sigma_AF_0_001	2.93e-02	4.56e-01	1.33e-01	2.65e-01
Result_uniqueEUR_sigma_AF_0_001 Exclusive	TIER1_GS Exclusive	4.46e-01	3.19e-01	3.11e-02	3.63e-02
TIER1_GS Exclusive	Result_uniqueEUR_sigma_AF_0_001 Exclusive	9.36e-03	3.39e-01	4.81e-01	7.01e-01
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Overlap	5.03e-01	7.04e-01	8.57e-01	5.94e-01
TIER1_GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	2.05e-04	1.85e-04	1.19e-04	1.32e-04



Evaluating how well Result_uniqueEUR_sigma_AF_0_001 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_0_001 Exclusive	TIER1_GS	0.61	0.65	0.86	0.23	2.26
TIER1_GS Exclusive	Result_uniqueEUR_sigma_AF_0_001	0.54	-0.15	0.03	0.04	1.39
Result_uniqueEUR_sigma_AF_0_001 Exclusive	TIER1_GS Exclusive	0.63	0.57	1.07	0.77	2.17
TIER1_GS Exclusive	Result_uniqueEUR_sigma_AF_0_001 Exclusive	0.53	-1.01	-0.55	-0.78	0.71
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Overlap	0.45	-1.00	-0.66	-0.76	-0.38
TIER1_GS Exclusive	Overlap	1.00	2.56	3.31	2.55	3.00
Overlap	Exclusives	0.63	2.09	3.91	2.49	4.07

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_0_001 Exclusive	TIER1_GS	0.00	-0.22	-0.26	-0.37	0.60
TIER1_GS Exclusive	Result_uniqueEUR_sigma_AF_0_001	0.01	4.73	22.16	14.89	18.94
Result_uniqueEUR_sigma_AF_0_001 Exclusive	TIER1_GS Exclusive	0.00	-0.39	-0.16	0.11	-0.04
TIER1_GS Exclusive	Result_uniqueEUR_sigma_AF_0_001 Exclusive	0.00	-0.04	0.68	0.29	0.43
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Overlap	0.00	-0.69	-0.34	-0.40	-0.25
TIER1_GS Exclusive	Overlap	0.21	542.39	237.87	189.58	723.22
Overlap	Exclusives	0.08	90.67	121.31	78.61	109.70

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Result_uniqueEUR_sigma_AF_0_001 Exclusive	75	74	TMEM269
TIER1_GS Exclusive	28	27	MS4A
Overlap	3	3