Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) Result_uniqueEUR_sigma_AF_0_001 tier2_gs 2.48e-03 4.11e-04 2.75e-06 8.19e-07 tier2_gs Result_uniqueEUR_sigma_AF_0_001 4.26e-01 5.92e-01 3.98e-02 1.72e-01 Evaluating how well Result_uniqueEUR_sigma_AF_0_001 genes are linked to tier2_gs genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Result_uniqueEUR_sigma_AF_0_001 tier2_gs 0.72 2.85 4.01 3.28 4.58 tier2_gs Result_uniqueEUR_sigma_AF_0_001 0.58 1.44 1.46 1.21 2.32 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Result_uniqueEUR_sigma_AF_0_001 tier2_gs 0.00 1.79 3.57 3.42 5.77 tier2_gs Result_uniqueEUR_sigma_AF_0_001 0.02 22.86 26.49 22.73 20.33 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes Result_uniqueEUR_sigma_AF_0_001 78 77 TMEM269 tier2_gs 46 43 IGH;TNSF13;TNSF12