Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Result_uniqueEUR_sigma_AF_0_001	AD_Ismael	2.29e-01	2.26e-01	1.59e-02	2.17e-03
AD_Ismael	Result_uniqueEUR_sigma_AF_0_001	7.01e-02	2.46e-01	9.64e-04	6.49e-02



Evaluating how well Result_uniqueEUR_sigma_AF_0_001 genes are linked to AD_Ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_0_001	AD_Ismael	0.78	1.00	2.02	1.62	3.65
AD_Ismael	Result_uniqueEUR_sigma_AF_0_001	0.57	1.21	1.47	1.01	2.21

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_0_001	AD_Ismael	0.00	0.17	2.98	2.11	5.07
AD_Ismael	Result_uniqueEUR_sigma_AF_0_001	0.01	1.66	0.38	1.57	0.98

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Result_uniqueEUR_sigma_AF_0_001	78	77	TMEM269
AD_Ismael	14	14