Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
osteo_female_top170 Exclusive	juv_onset	8.29e-01	5.69e-01	8.66e-01	1.14e-02
juv_onset Exclusive	osteo_female_top170	1.22e-02	9.80e-01	3.94e-01	7.81e-01
osteo_female_top170 Exclusive	juv_onset Exclusive	8.51e-01	6.17e-01	6.42e-01	2.24e-02
juv_onset Exclusive	osteo_female_top170 Exclusive	9.28e-03	9.89e-01	6.75e-01	8.33e-01
osteo_female_top170 Exclusive	Overlap	3.82e-01	5.57e-01	4.85e-01	7.71e-02
juv_onset Exclusive	Overlap	5.23e-05	3.66e-05	4.36e-06	7.19e-05
Overlap	Exclusives	2.11e-17	4.06e-16	1.64e-39	8.48e-18



Evaluating how well osteo_female_top170 genes are linked to juv_onset genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
osteo_female_top170 Exclusive	juv_onset	0.59	0.43	0.42	0.54	3.30
juv_onset Exclusive	osteo_female_top170	0.51	0.41	0.15	0.28	0.24
osteo_female_top170 Exclusive	juv_onset Exclusive	0.58	0.32	0.22	0.25	3.03
juv_onset Exclusive	osteo_female_top170 Exclusive	0.50	0.11	0.02	0.40	-0.19
osteo_female_top170 Exclusive	Overlap	0.81	1.17	1.22	1.23	1.82
juv_onset Exclusive	Overlap	0.99	2.11	3.29	2.45	3.75
Overlap	Exclusives	0.68	8.56	10.46	5.43	9.69

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
osteo_female_top170 Exclusive	juv_onset	0.01	-0.12	-0.36	-0.04	1.60
juv_onset Exclusive	osteo_female_top170	0.02	16.51	26.50	19.64	15.98
osteo_female_top170 Exclusive	juv_onset Exclusive	0.01	-0.21	-0.36	-0.32	1.46
juv_onset Exclusive	osteo_female_top170 Exclusive	0.01	0.64	-0.02	0.06	-0.46
osteo_female_top170 Exclusive	Overlap	0.00	0.39	0.67	0.06	-0.04
juv_onset Exclusive	Overlap	0.67	1221.73	6414.87	1787.99	482.66
Overlap	Exclusives	0.06	47.87	52.38	26.73	56.66

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
osteo_female_top170 Exclusive	167	162	EDDM13;AGAP9;ZNF559-ZNF177;HSFX3;INAFM2
juv_onset Exclusive	123	123	
Overlap	3	3