Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_10 Exclusive	tier1_31	4.92e-10	8.15e-11	7.25e-11	7.46e-11
tier1_31 Exclusive	Result_uniqueEUR_sigma_AF_001_10	5.15e-02	7.31e-02	2.31e-03	7.58e-03
Result_uniqueEUR_sigma_AF_001_10 Exclusive	tier1_31 Exclusive	1.52e-08	2.39e-08	5.75e-09	5.15e-09
tier1_31 Exclusive	Result_uniqueEUR_sigma_AF_001_10 Exclusive	1.25e-01	1.25e-01	8.06e-03	2.92e-02
Result_uniqueEUR_sigma_AF_001_10 Exclusive	Overlap	6.71e-04	4.36e-07	3.66e-05	2.44e-05
tier1_31 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	1.21e-05	8.30e-05	2.42e-20	4.09e-08



Evaluating how well Result_uniqueEUR_sigma_AF_001_10 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_10 Exclusive	tier1_31	0.87	4.66	7.50	4.46	7.20
tier1_31 Exclusive	Result_uniqueEUR_sigma_AF_001_10	0.57	2.01	1.48	2.24	2.71
Result_uniqueEUR_sigma_AF_001_10 Exclusive	tier1_31 Exclusive	0.86	5.98	7.45	3.70	7.70
tier1_31 Exclusive	Result_uniqueEUR_sigma_AF_001_10 Exclusive	0.56	1.47	1.24	1.68	2.50
Result_uniqueEUR_sigma_AF_001_10 Exclusive	Overlap	0.99	2.14	2.82	2.68	2.93
tier1_31 Exclusive	Overlap	1.00	2.62	3.08	2.69	3.12
Overlap	Exclusives	0.65	6.08	5.80	3.89	6.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_10 Exclusive	tier1_31	0.05	70.56	127.01	57.32	87.76
tier1_31 Exclusive	Result_uniqueEUR_sigma_AF_001_10	0.03	36.92	34.23	31.63	30.90
Result_uniqueEUR_sigma_AF_001_10 Exclusive	tier1_31 Exclusive	0.04	92.71	108.14	34.48	68.48
tier1_31 Exclusive	Result_uniqueEUR_sigma_AF_001_10 Exclusive	0.03	30.39	33.23	25.78	32.14
Result_uniqueEUR_sigma_AF_001_10 Exclusive	Overlap	0.02	16.17	86.68	36.53	6.39
tier1_31 Exclusive	Overlap	0.06	99.09	286.01	56.01	180.96
Overlap	Exclusives	0.07	51.64	80.85	33.98	82.16

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Result_uniqueEUR_sigma_AF_001_10 Exclusive	137	135	RFPL2;AC245033.1
tier1_31 Exclusive	28	27	MS4A
Overlap	3	3