Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_10 Exclusive	tier2_gs	2.34e-01	2.20e-02	1.68e-02	9.89e-04
tier2_gs Exclusive	Result_uniqueEUR_sigma_AF_001_10	2.57e-01	2.04e-01	1.16e-04	1.49e-02
Result_uniqueEUR_sigma_AF_001_10 Exclusive	tier2_gs Exclusive	1.74e-01	3.13e-02	2.23e-02	1.57e-03
tier2_gs Exclusive	Result_uniqueEUR_sigma_AF_001_10 Exclusive	2.98e-01	2.33e-01	5.53e-04	1.34e-02
Result_uniqueEUR_sigma_AF_001_10 Exclusive	Overlap	6.14e-01	5.54e-01	1.98e-01	3.17e-01
tier2_gs Exclusive	Overlap	2.38e-01	5.15e-01	2.18e-01	4.75e-01
Overlap	Exclusives	4.29e-02	5.00e-02	5.33e-06	5.35e-05



Evaluating how well Result_uniqueEUR_sigma_AF_001_10 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_10 Exclusive	tier2_gs	0.65	0.68	1.93	1.30	3.53
tier2_gs Exclusive	Result_uniqueEUR_sigma_AF_001_10	0.57	1.99	1.29	2.11	2.96
Result_uniqueEUR_sigma_AF_001_10 Exclusive	tier2_gs Exclusive	0.65	0.65	1.82	1.40	3.13
tier2_gs Exclusive	Result_uniqueEUR_sigma_AF_001_10 Exclusive	0.56	1.83	1.20	1.73	2.48
Result_uniqueEUR_sigma_AF_001_10 Exclusive	Overlap	0.81	0.80	0.71	1.16	1.21
tier2_gs Exclusive	Overlap	0.84	1.28	0.94	1.16	1.01
Overlap	Exclusives	0.58	1.75	1.88	1.06	4.20

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_10 Exclusive	tier2_gs	0.01	3.54	10.35	6.69	14.79
tier2_gs Exclusive	Result_uniqueEUR_sigma_AF_001_10	0.01	4.17	4.95	3.92	4.94
Result_uniqueEUR_sigma_AF_001_10 Exclusive	tier2_gs Exclusive	0.01	3.81	11.49	8.40	5.69
tier2_gs Exclusive	Result_uniqueEUR_sigma_AF_001_10 Exclusive	0.01	6.36	3.06	5.42	3.53
Result_uniqueEUR_sigma_AF_001_10 Exclusive	Overlap	0.00	0.12	-0.12	0.07	-0.09
tier2_gs Exclusive	Overlap	0.00	0.35	-0.15	0.21	-0.05
Overlap	Exclusives	0.01	1.39	1.91	0.54	4.31

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Result_uniqueEUR_sigma_AF_001_10 Exclusive	139	137	RFPL2;AC245033.1
tier2_gs Exclusive	45	42	IGH;TNSF12;TNSF13
Overlap	1	1