Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_10	Ismael_14_AD	4.12e-01	3.39e-01	1.02e-01	3.04e-03
Ismael_14_AD	Result_uniqueEUR_sigma_AF_001_10	1.34e-01	4.99e-01	5.52e-07	7.87e-02



Evaluating how well Result_uniqueEUR_sigma_AF_001_10 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_10	Ismael_14_AD	0.76	0.60	1.78	1.27	3.83
Ismael_14_AD	Result_uniqueEUR_sigma_AF_001_10	0.56	2.41	1.19	1.66	2.41

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_10	Ismael_14_AD	0.00	1.82	7.25	4.20	11.28
Ismael_14_AD	Result_uniqueEUR_sigma_AF_001_10	0.01	2.94	1.57	1.80	2.80

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Result_uniqueEUR_sigma_AF_001_10	140	138	AC245033.1;RFPL2
Ismael_14_AD	14	14