Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Feixiong group AD test Exclusive	Sigma_AD_R2 _122	3.31e-03	1.47e-03	1.64e-04	3.16e-06
Sigma_AD_R2 _122 Exclusive	Feixiong group AD test	4.13e-06	5.75e-05	1.39e-09	1.67e-06
Feixiong group AD test Exclusive	Sigma_AD_R2 _122 Exclusive	1.21e-01	5.13e-02	1.20e-02	1.41e-03
Sigma_AD_R2 _122 Exclusive	Feixiong group AD test Exclusive	9.97e-06	1.04e-04	1.08e-09	4.69e-06
Feixiong group AD test Exclusive	Overlap	1.99e-06	7.62e-07	1.19e-06	6.01e-09
Sigma_AD_R2 _122 Exclusive	Overlap	1.39e-01	7.80e-02	5.20e-02	1.19e-02
Overlap	Exclusives	2.65e-09	2.49e-15	1.29e-29	1.00e-17



Evaluating how well Feixiong group AD test genes are linked to Sigma_AD_R2 _122 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Feixiong group AD test Exclusive	Sigma_AD_R2 _122	0.63	4.77	4.30	5.36	4.51
Sigma_AD_R2 _122 Exclusive	Feixiong group AD test	0.58	3.70	4.66	3.69	5.70
Feixiong group AD test Exclusive	Sigma_AD_R2 _122 Exclusive	0.60	3.47	2.92	3.47	4.08
Sigma_AD_R2 _122 Exclusive	Feixiong group AD test Exclusive	0.58	3.80	6.03	3.84	5.76
Feixiong group AD test Exclusive	Overlap	0.91	6.50	6.45	5.33	5.14
Sigma_AD_R2 _122 Exclusive	Overlap	0.76	2.62	3.51	2.69	2.95
Overlap	Exclusives	0.63	6.86	12.51	6.19	11.00

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Feixiong group AD test Exclusive	Sigma_AD_R2 _122	0.03	33.66	27.51	37.48	19.48
Sigma_AD_R2 _122 Exclusive	Feixiong group AD test	0.03	5.25	8.50	7.03	9.39
Feixiong group AD test Exclusive	Sigma_AD_R2 _122 Exclusive	0.01	6.90	4.16	8.40	3.94
Sigma_AD_R2 _122 Exclusive	Feixiong group AD test Exclusive	0.03	6.60	12.45	7.29	10.06
Feixiong group AD test Exclusive	Overlap	0.09	235.22	270.09	37.93	123.35
Sigma_AD_R2 _122 Exclusive	Overlap	0.00	0.46	1.30	0.04	3.13
Overlap	Exclusives	0.08	28.08	53.78	26.28	47.70

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Feixiong group AD test Exclusive	435	415	OR2J1;IGHV3-66;IGHV3-64;C17orf107;TRIM39-RPP21;IGHV3-73;IGHV1-69;IGHV3-53;IGHV3-74;IGHG2;IGHA1;APOC4-APOC2;ATP6V1G2-DDX39B;IGHV4-59;IGHV4-61;IGHV1-58;IGHV3-72;IGHG3;IGHG1;IGHV2-70
Sigma_AD_R2 _122 Exclusive	109	108	RFPL2
Overlap	13	13