Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) Feixiong group AD test Exclusive EAML_159 1.60e-02 4.85e-04 4.58e-04 5.42e-04 EAML_159 Exclusive Feixiong group AD test 8.03e-03 6.25e-02 5.58e-03 1.66e-02 Feixiong group AD test Exclusive EAML_159 Exclusive 2.38e-01 2.05e-02 3.67e-02 5.53e-02 EAML_159 Exclusive Feixiong group AD test Exclusive 1.12e-02 5.56e-02 5.42e-03 1.77e-02 Feixiong group AD test Exclusive Overlap 2.98e-06 7.98e-06 4.35e-07 1.06e-07 EAML_159 Exclusive Overlap 5.09e-02 7.73e-02 8.95e-02 3.62e-02 Overlap Exclusives 6.57e-08 5.21e-12 6.27e-19 8.58e-14 Evaluating how well Feixiong group AD test genes are linked to EAML_159 genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Feixiong group AD test Exclusive EAML_159 0.57 4.06 4.26 4.00 3.28 EAML_159 Exclusive Feixiong group AD test 0.55 2.24 1.78 2.27 3.09 Feixiong group AD test Exclusive EAML_159 Exclusive 0.54 2.61 2.49 2.46 1.97 EAML_159 Exclusive Feixiong group AD test Exclusive 0.54 1.73 1.83 2.01 2.83 Feixiong group AD test Exclusive Overlap 0.89 6.81 6.44 5.41 5.61 EAML_159 Exclusive Overlap 0.66 1.86 1.66 1.60 2.05 Overlap Exclusives 0.61 5.52 9.97 4.90 10.17 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Feixiong group AD test Exclusive EAML_159 0.03 38.88 39.79 13.11 32.96 EAML_159 Exclusive Feixiong group AD test 0.03 2.99 2.90 2.87 3.74 Feixiong group AD test Exclusive EAML_159 Exclusive 0.01 2.69 3.45 0.56 3.10 EAML_159 Exclusive Feixiong group AD test Exclusive 0.03 2.44 3.08 2.69 3.61 Feixiong group AD test Exclusive Overlap 0.18 605.20 352.86 134.29 149.04 EAML_159 Exclusive Overlap 0.00 0.32 -0.65 -0.08 0.70 Overlap Exclusives 0.08 28.67 53.54 27.66 51.05 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes Feixiong group AD test Exclusive 433 413 C17orf107;IGHG1;IGHV1-58;IGHV2-70;IGHA1;IGHV4-59;OR2J1;IGHG2;IGHV1-69;IGHG3;IGHV3-73;IGHV3-74;APOC4-APOC2;IGHV3-66;TRIM39-RPP21;IGHV3-64;IGHV4-61;IGHV3-53;IGHV3-72;ATP6V1G2-DDX39B EAML_159 Exclusive 144 142 RFPL2;AL162417.1 Overlap 15 15