Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Feixiong group AD test Exclusive	EAML_159	1.60e-02	4.85e-04	4.58e-04	5.42e-04
EAML_159 Exclusive	Feixiong group AD test	8.03e-03	6.25e-02	5.58e-03	1.66e-02
Feixiong group AD test Exclusive	EAML_159 Exclusive	2.38e-01	2.05e-02	3.67e-02	5.53e-02
EAML_159 Exclusive	Feixiong group AD test Exclusive	1.12e-02	5.56e-02	5.42e-03	1.77e-02
Feixiong group AD test Exclusive	Overlap	2.98e-06	7.98e-06	4.35e-07	1.06e-07
EAML_159 Exclusive	Overlap	5.09e-02	7.73e-02	8.95e-02	3.62e-02
Overlap	Exclusives	6.57e-08	5.21e-12	6.27e-19	8.58e-14



Evaluating how well Feixiong group AD test genes are linked to EAML_159 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Feixiong group AD test Exclusive	EAML_159	0.57	4.06	4.26	4.00	3.28
EAML_159 Exclusive	Feixiong group AD test	0.55	2.24	1.78	2.27	3.09
Feixiong group AD test Exclusive	EAML_159 Exclusive	0.54	2.61	2.49	2.46	1.97
EAML_159 Exclusive	Feixiong group AD test Exclusive	0.54	1.73	1.83	2.01	2.83
Feixiong group AD test Exclusive	Overlap	0.89	6.81	6.44	5.41	5.61
EAML_159 Exclusive	Overlap	0.66	1.86	1.66	1.60	2.05
Overlap	Exclusives	0.61	5.52	9.97	4.90	10.17

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Feixiong group AD test Exclusive	EAML_159	0.03	38.88	39.79	13.11	32.96
EAML_159 Exclusive	Feixiong group AD test	0.03	2.99	2.90	2.87	3.74
Feixiong group AD test Exclusive	EAML_159 Exclusive	0.01	2.69	3.45	0.56	3.10
EAML_159 Exclusive	Feixiong group AD test Exclusive	0.03	2.44	3.08	2.69	3.61
Feixiong group AD test Exclusive	Overlap	0.18	605.20	352.86	134.29	149.04
EAML_159 Exclusive	Overlap	0.00	0.32	-0.65	-0.08	0.70
Overlap	Exclusives	0.08	28.67	53.54	27.66	51.05

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Feixiong group AD test Exclusive	433	413	C17orf107;IGHG1;IGHV1-58;IGHV2-70;IGHA1;IGHV4-59;OR2J1;IGHG2;IGHV1-69;IGHG3;IGHV3-73;IGHV3-74;APOC4-APOC2;IGHV3-66;TRIM39-RPP21;IGHV3-64;IGHV4-61;IGHV3-53;IGHV3-72;ATP6V1G2-DDX39B
EAML_159 Exclusive	144	142	RFPL2;AL162417.1
Overlap	15	15