Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wav470 Exclusive	GWAS	2.92e-01	4.38e-01	2.85e-16	5.04e-10
GWAS Exclusive	Wav470	6.18e-02	5.41e-02	3.51e-15	1.72e-20
Wav470 Exclusive	GWAS Exclusive	8.52e-01	5.54e-01	1.66e-13	2.70e-08
GWAS Exclusive	Wav470 Exclusive	9.40e-02	4.60e-01	1.10e-09	1.51e-15
Wav470 Exclusive	Overlap	3.48e-02	6.09e-03	1.71e-09	1.24e-07
GWAS Exclusive	Overlap	5.22e-05	4.12e-04	1.47e-10	1.87e-10
Overlap	Exclusives	3.71e-08	1.15e-07	5.90e-24	3.26e-30



Evaluating how well Wav470 genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wav470 Exclusive	GWAS	0.65	1.31	1.37	2.25	7.94
GWAS Exclusive	Wav470	0.74	-0.16	2.44	2.12	11.64
Wav470 Exclusive	GWAS Exclusive	0.63	1.01	0.76	1.98	6.31
GWAS Exclusive	Wav470 Exclusive	0.72	-1.11	1.29	1.58	10.28
Wav470 Exclusive	Overlap	0.90	1.26	3.07	2.90	5.16
GWAS Exclusive	Overlap	0.93	2.86	3.78	3.82	5.08
Overlap	Exclusives	0.71	2.36	6.54	3.65	14.17

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wav470 Exclusive	GWAS	0.02	0.48	1.06	3.08	6.53
GWAS Exclusive	Wav470	0.03	0.29	3.27	5.29	20.65
Wav470 Exclusive	GWAS Exclusive	0.01	-0.32	-0.10	2.23	4.23
GWAS Exclusive	Wav470 Exclusive	0.02	-1.96	-0.28	1.96	10.92
Wav470 Exclusive	Overlap	0.01	1.69	0.81	5.14	22.23
GWAS Exclusive	Overlap	0.03	12.36	31.97	42.17	75.74
Overlap	Exclusives	0.05	5.40	12.14	11.66	29.45

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wav470 Exclusive	167	167	
GWAS Exclusive	200	181	FLJ12334;LOC100506393;PARTICL;MIR4432;TEX41;LOC339894;CDKN2B-AS1;NCRNA00310;LOC646736;LOC400043;LOC145820;TARID;MCF2L-AS1;LOC100131060;SNORD123;LOC283033;IRF-AS1;MIR4693;C9orf146
Overlap	16	16