Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
test_set Exclusive	osteo_bio	1.79e-05	4.18e-03	2.34e-05	7.67e-09
osteo_bio Exclusive	test_set	3.49e-06	5.29e-01	5.60e-02	5.81e-01
test_set Exclusive	osteo_bio Exclusive	4.68e-05	5.23e-03	4.74e-04	1.04e-08
osteo_bio Exclusive	test_set Exclusive	3.20e-06	6.71e-01	9.89e-02	8.53e-01
test_set Exclusive	Overlap	6.93e-02	1.80e-01	1.26e-01	1.31e-01
osteo_bio Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	3.93e-05	1.51e-06	5.62e-08	9.29e-08



Evaluating how well test_set genes are linked to osteo_bio genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
test_set Exclusive	osteo_bio	0.82	2.13	4.04	1.56	6.45
osteo_bio Exclusive	test_set	0.52	0.51	0.41	0.29	0.77
test_set Exclusive	osteo_bio Exclusive	0.82	1.97	3.96	1.35	6.38
osteo_bio Exclusive	test_set Exclusive	0.51	0.25	0.17	-0.26	0.37
test_set Exclusive	Overlap	0.87	1.75	1.61	1.49	1.82
osteo_bio Exclusive	Overlap	1.00	1.98	2.38	2.40	2.44
Overlap	Exclusives	0.60	1.63	2.45	1.51	4.40

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
test_set Exclusive	osteo_bio	0.01	2.49	5.86	1.08	3.65
osteo_bio Exclusive	test_set	0.02	19.07	27.21	16.81	16.53
test_set Exclusive	osteo_bio Exclusive	0.00	1.78	5.35	0.84	4.38
osteo_bio Exclusive	test_set Exclusive	0.01	1.35	1.84	0.61	1.07
test_set Exclusive	Overlap	0.00	4.48	2.72	1.66	0.06
osteo_bio Exclusive	Overlap	0.60	2285.98	2281.28	1983.68	450.51
Overlap	Exclusives	0.04	26.46	58.24	25.07	35.92

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
test_set Exclusive	117	116	IQANK1
osteo_bio Exclusive	30	30	
Overlap	2	2