Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Feixiong group AD test Exclusive	Sigma_AD_WGS_EA_R4_116	6.56e-02	1.33e-01	1.54e-02	1.67e-01
Sigma_AD_WGS_EA_R4_116 Exclusive	Feixiong group AD test	5.27e-02	4.46e-02	2.57e-02	2.54e-03
Feixiong group AD test Exclusive	Sigma_AD_WGS_EA_R4_116 Exclusive	1.19e-01	7.88e-01	3.80e-01	8.01e-01
Sigma_AD_WGS_EA_R4_116 Exclusive	Feixiong group AD test Exclusive	4.28e-02	5.26e-02	3.80e-02	1.39e-03
Feixiong group AD test Exclusive	Overlap	2.14e-07	1.58e-05	8.35e-08	1.68e-07
Sigma_AD_WGS_EA_R4_116 Exclusive	Overlap	9.88e-01	9.30e-01	9.90e-01	6.27e-01
Overlap	Exclusives	2.90e-10	2.78e-14	1.81e-10	8.14e-17



Evaluating how well Feixiong group AD test genes are linked to Sigma_AD_WGS_EA_R4_116 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Feixiong group AD test Exclusive	Sigma_AD_WGS_EA_R4_116	0.54	2.82	2.31	2.69	1.44
Sigma_AD_WGS_EA_R4_116 Exclusive	Feixiong group AD test	0.56	2.50	3.72	2.75	4.10
Feixiong group AD test Exclusive	Sigma_AD_WGS_EA_R4_116 Exclusive	0.51	0.78	0.30	1.03	0.19
Sigma_AD_WGS_EA_R4_116 Exclusive	Feixiong group AD test Exclusive	0.56	2.87	3.10	2.97	4.04
Feixiong group AD test Exclusive	Overlap	0.88	6.60	6.15	6.96	3.50
Sigma_AD_WGS_EA_R4_116 Exclusive	Overlap	0.42	-0.04	-0.67	-0.11	-0.63
Overlap	Exclusives	0.63	6.58	11.29	5.55	9.92

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Feixiong group AD test Exclusive	Sigma_AD_WGS_EA_R4_116	0.02	43.58	9.16	9.91	12.64
Sigma_AD_WGS_EA_R4_116 Exclusive	Feixiong group AD test	0.03	1.29	2.17	2.11	2.68
Feixiong group AD test Exclusive	Sigma_AD_WGS_EA_R4_116 Exclusive	0.01	5.55	1.19	5.37	1.49
Sigma_AD_WGS_EA_R4_116 Exclusive	Feixiong group AD test Exclusive	0.03	2.11	2.05	2.26	2.59
Feixiong group AD test Exclusive	Overlap	0.10	297.13	137.67	50.10	240.73
Sigma_AD_WGS_EA_R4_116 Exclusive	Overlap	0.00	-0.32	-0.71	-0.42	-0.52
Overlap	Exclusives	0.08	24.81	45.65	21.86	41.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Feixiong group AD test Exclusive	439	419	C17orf107;IGHV4-61;IGHV1-58;IGHG2;IGHV3-72;OR2J1;IGHV2-70;IGHV1-69;IGHV3-53;IGHV3-66;IGHV3-74;TRIM39-RPP21;IGHV4-59;IGHA1;IGHV3-73;APOC4-APOC2;IGHG1;IGHV3-64;IGHG3;ATP6V1G2-DDX39B
Sigma_AD_WGS_EA_R4_116 Exclusive	107	104	EDDM13;VNN 3.00;CHURC1-FNTB
Overlap	9	9