Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) Feixiong group AD test Exclusive Sigma_AD_WGS_EA_R4_116 6.56e-02 1.33e-01 1.54e-02 1.67e-01 Sigma_AD_WGS_EA_R4_116 Exclusive Feixiong group AD test 5.27e-02 4.46e-02 2.57e-02 2.54e-03 Feixiong group AD test Exclusive Sigma_AD_WGS_EA_R4_116 Exclusive 1.19e-01 7.88e-01 3.80e-01 8.01e-01 Sigma_AD_WGS_EA_R4_116 Exclusive Feixiong group AD test Exclusive 4.28e-02 5.26e-02 3.80e-02 1.39e-03 Feixiong group AD test Exclusive Overlap 2.14e-07 1.58e-05 8.35e-08 1.68e-07 Sigma_AD_WGS_EA_R4_116 Exclusive Overlap 9.88e-01 9.30e-01 9.90e-01 6.27e-01 Overlap Exclusives 2.90e-10 2.78e-14 1.81e-10 8.14e-17 Evaluating how well Feixiong group AD test genes are linked to Sigma_AD_WGS_EA_R4_116 genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Feixiong group AD test Exclusive Sigma_AD_WGS_EA_R4_116 0.54 2.82 2.31 2.69 1.44 Sigma_AD_WGS_EA_R4_116 Exclusive Feixiong group AD test 0.56 2.50 3.72 2.75 4.10 Feixiong group AD test Exclusive Sigma_AD_WGS_EA_R4_116 Exclusive 0.51 0.78 0.30 1.03 0.19 Sigma_AD_WGS_EA_R4_116 Exclusive Feixiong group AD test Exclusive 0.56 2.87 3.10 2.97 4.04 Feixiong group AD test Exclusive Overlap 0.88 6.60 6.15 6.96 3.50 Sigma_AD_WGS_EA_R4_116 Exclusive Overlap 0.42 -0.04 -0.67 -0.11 -0.63 Overlap Exclusives 0.63 6.58 11.29 5.55 9.92 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Feixiong group AD test Exclusive Sigma_AD_WGS_EA_R4_116 0.02 43.58 9.16 9.91 12.64 Sigma_AD_WGS_EA_R4_116 Exclusive Feixiong group AD test 0.03 1.29 2.17 2.11 2.68 Feixiong group AD test Exclusive Sigma_AD_WGS_EA_R4_116 Exclusive 0.01 5.55 1.19 5.37 1.49 Sigma_AD_WGS_EA_R4_116 Exclusive Feixiong group AD test Exclusive 0.03 2.11 2.05 2.26 2.59 Feixiong group AD test Exclusive Overlap 0.10 297.13 137.67 50.10 240.73 Sigma_AD_WGS_EA_R4_116 Exclusive Overlap 0.00 -0.32 -0.71 -0.42 -0.52 Overlap Exclusives 0.08 24.81 45.65 21.86 41.00 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes Feixiong group AD test Exclusive 439 419 C17orf107;IGHV4-61;IGHV1-58;IGHG2;IGHV3-72;OR2J1;IGHV2-70;IGHV1-69;IGHV3-53;IGHV3-66;IGHV3-74;TRIM39-RPP21;IGHV4-59;IGHA1;IGHV3-73;APOC4-APOC2;IGHG1;IGHV3-64;IGHG3;ATP6V1G2-DDX39B Sigma_AD_WGS_EA_R4_116 Exclusive 107 104 EDDM13;VNN 3.00;CHURC1-FNTB Overlap 9 9