Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Feixiong group AD test Exclusive	UKB_AD_101	2.97e-02	4.06e-01	1.71e-02	9.89e-02
UKB_AD_101 Exclusive	Feixiong group AD test	3.02e-01	2.76e-01	1.83e-03	6.47e-02
Feixiong group AD test Exclusive	UKB_AD_101 Exclusive	1.35e-02	6.08e-01	1.32e-01	7.63e-01
UKB_AD_101 Exclusive	Feixiong group AD test Exclusive	2.62e-01	3.27e-01	6.70e-04	9.40e-02
Feixiong group AD test Exclusive	Overlap	3.58e-06	1.91e-04	1.80e-06	1.25e-08
UKB_AD_101 Exclusive	Overlap	5.73e-02	4.53e-01	7.27e-02	1.68e-02
Overlap	Exclusives	1.39e-04	1.66e-11	2.49e-40	3.98e-13



Evaluating how well Feixiong group AD test genes are linked to UKB_AD_101 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Feixiong group AD test Exclusive	UKB_AD_101	0.56	0.75	0.55	0.62	2.07
UKB_AD_101 Exclusive	Feixiong group AD test	0.54	1.01	1.41	1.41	2.76
Feixiong group AD test Exclusive	UKB_AD_101 Exclusive	0.52	-0.88	-0.70	-0.55	0.71
UKB_AD_101 Exclusive	Feixiong group AD test Exclusive	0.53	0.88	1.19	1.49	2.40
Feixiong group AD test Exclusive	Overlap	0.97	5.28	5.12	5.21	4.79
UKB_AD_101 Exclusive	Overlap	0.74	1.77	1.18	1.38	2.35
Overlap	Exclusives	0.62	5.42	11.30	4.57	8.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Feixiong group AD test Exclusive	UKB_AD_101	0.02	32.38	16.75	28.53	21.61
UKB_AD_101 Exclusive	Feixiong group AD test	0.02	0.95	1.42	1.59	2.60
Feixiong group AD test Exclusive	UKB_AD_101 Exclusive	0.01	5.08	3.25	3.27	1.57
UKB_AD_101 Exclusive	Feixiong group AD test Exclusive	0.02	0.96	1.22	1.41	1.98
Feixiong group AD test Exclusive	Overlap	0.06	147.95	50.63	151.58	140.88
UKB_AD_101 Exclusive	Overlap	0.00	1.65	-0.40	1.11	0.52
Overlap	Exclusives	0.08	21.13	51.63	17.33	44.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Feixiong group AD test Exclusive	439	419	IGHV2-70;IGHV1-58;IGHV3-66;ATP6V1G2-DDX39B;C17orf107;IGHV4-59;IGHV3-74;IGHV3-53;IGHV3-64;IGHV3-73;IGHA1;IGHV3-72;TRIM39-RPP21;IGHG1;IGHV4-61;IGHV1-69;IGHG3;IGHG2;OR2J1;APOC4-APOC2
UKB_AD_101 Exclusive	92	92	
Overlap	9	9