Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Feixiong group AD test Exclusive	UKB_AD_Proxy _95	4.55e-02	1.31e-01	1.57e-02	1.73e-03
UKB_AD_Proxy _95 Exclusive	Feixiong group AD test	6.67e-02	2.84e-01	1.63e-05	6.62e-03
Feixiong group AD test Exclusive	UKB_AD_Proxy _95 Exclusive	7.49e-01	6.30e-01	4.32e-01	5.71e-02
UKB_AD_Proxy _95 Exclusive	Feixiong group AD test Exclusive	3.37e-02	2.07e-01	3.12e-05	1.01e-02
Feixiong group AD test Exclusive	Overlap	2.42e-06	3.22e-04	1.03e-06	3.03e-06
UKB_AD_Proxy _95 Exclusive	Overlap	1.00e+00	9.40e-01	9.20e-01	9.70e-01
Overlap	Exclusives	5.68e-06	3.72e-12	6.93e-19	3.06e-14



Evaluating how well Feixiong group AD test genes are linked to UKB_AD_Proxy _95 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Feixiong group AD test Exclusive	UKB_AD_Proxy _95	0.61	2.48	2.62	2.88	3.54
UKB_AD_Proxy _95 Exclusive	Feixiong group AD test	0.54	2.19	1.65	1.92	3.17
Feixiong group AD test Exclusive	UKB_AD_Proxy _95 Exclusive	0.57	0.49	0.80	0.91	1.76
UKB_AD_Proxy _95 Exclusive	Feixiong group AD test Exclusive	0.54	2.28	2.07	1.63	3.02
Feixiong group AD test Exclusive	Overlap	0.88	5.77	5.34	4.92	4.56
UKB_AD_Proxy _95 Exclusive	Overlap	0.56	0.05	-0.15	0.13	0.52
Overlap	Exclusives	0.63	7.40	12.67	5.65	10.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Feixiong group AD test Exclusive	UKB_AD_Proxy _95	0.04	65.32	61.09	27.33	54.79
UKB_AD_Proxy _95 Exclusive	Feixiong group AD test	0.02	1.41	0.98	1.63	1.79
Feixiong group AD test Exclusive	UKB_AD_Proxy _95 Exclusive	0.01	2.02	3.30	2.67	3.00
UKB_AD_Proxy _95 Exclusive	Feixiong group AD test Exclusive	0.02	1.80	1.62	1.30	2.18
Feixiong group AD test Exclusive	Overlap	0.20	439.63	212.05	107.07	165.68
UKB_AD_Proxy _95 Exclusive	Overlap	0.00	-0.45	-0.43	-0.35	-0.22
Overlap	Exclusives	0.08	29.45	64.68	30.88	54.74

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Feixiong group AD test Exclusive	436	416	IGHV3-73;IGHV1-69;IGHV1-58;IGHV4-61;ATP6V1G2-DDX39B;IGHG3;IGHV3-53;IGHA1;IGHG2;IGHV3-72;TRIM39-RPP21;IGHV3-74;C17orf107;IGHV4-59;IGHV3-66;IGHG1;IGHV3-64;APOC4-APOC2;IGHV2-70;OR2J1
UKB_AD_Proxy _95 Exclusive	83	80	SERPINA3;TMEM265;KDM5D
Overlap	12	12