Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigmaEA_WESR2_122 Exclusive	Result_uniqueEUR_sigma_AF_001_10	2.53e-01	6.68e-02	4.51e-04	1.22e-03
Result_uniqueEUR_sigma_AF_001_10 Exclusive	sigmaEA_WESR2_122	3.17e-01	3.90e-01	1.02e-03	3.08e-02
sigmaEA_WESR2_122 Exclusive	Result_uniqueEUR_sigma_AF_001_10 Exclusive	3.13e-01	3.16e-01	2.69e-02	8.00e-03
Result_uniqueEUR_sigma_AF_001_10 Exclusive	sigmaEA_WESR2_122 Exclusive	3.74e-01	4.96e-01	8.63e-02	6.52e-02
sigmaEA_WESR2_122 Exclusive	Overlap	6.47e-01	1.45e-01	1.08e-02	5.78e-02
Result_uniqueEUR_sigma_AF_001_10 Exclusive	Overlap	4.95e-01	4.34e-01	1.17e-02	1.21e-01
Overlap	Exclusives	8.98e-01	9.30e-01	7.07e-01	7.33e-02



Evaluating how well sigmaEA_WESR2_122 genes are linked to Result_uniqueEUR_sigma_AF_001_10 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigmaEA_WESR2_122 Exclusive	Result_uniqueEUR_sigma_AF_001_10	0.58	2.28	2.28	2.61	3.52
Result_uniqueEUR_sigma_AF_001_10 Exclusive	sigmaEA_WESR2_122	0.56	1.08	1.00	1.45	2.39
sigmaEA_WESR2_122 Exclusive	Result_uniqueEUR_sigma_AF_001_10 Exclusive	0.60	2.16	2.05	1.62	2.67
Result_uniqueEUR_sigma_AF_001_10 Exclusive	sigmaEA_WESR2_122 Exclusive	0.60	1.58	1.29	1.74	2.42
sigmaEA_WESR2_122 Exclusive	Overlap	0.56	1.01	1.42	1.69	1.82
Result_uniqueEUR_sigma_AF_001_10 Exclusive	Overlap	0.53	0.18	0.29	0.65	1.10
Overlap	Exclusives	0.56	-0.24	0.22	0.58	2.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigmaEA_WESR2_122 Exclusive	Result_uniqueEUR_sigma_AF_001_10	0.01	1.83	2.22	1.52	3.20
Result_uniqueEUR_sigma_AF_001_10 Exclusive	sigmaEA_WESR2_122	0.01	1.04	0.89	1.19	1.83
sigmaEA_WESR2_122 Exclusive	Result_uniqueEUR_sigma_AF_001_10 Exclusive	0.00	1.74	2.38	2.72	0.51
Result_uniqueEUR_sigma_AF_001_10 Exclusive	sigmaEA_WESR2_122 Exclusive	0.00	2.64	1.63	2.48	2.87
sigmaEA_WESR2_122 Exclusive	Overlap	0.00	0.56	0.60	1.05	0.47
Result_uniqueEUR_sigma_AF_001_10 Exclusive	Overlap	0.00	-0.33	-0.19	-0.06	-0.01
Overlap	Exclusives	0.01	0.70	0.55	1.72	3.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigmaEA_WESR2_122 Exclusive	46	46	
Result_uniqueEUR_sigma_AF_001_10 Exclusive	64	63	AC245033.1
Overlap	76	75	RFPL2