Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigmaEA_WESR2_122 Exclusive	Result_uniqueEUR_sigma_AF_0_001	2.61e-01	3.35e-01	5.00e-02	1.04e-02
Result_uniqueEUR_sigma_AF_0_001 Exclusive	sigmaEA_WESR2_122	1.15e-01	2.53e-01	7.33e-03	9.59e-02
sigmaEA_WESR2_122 Exclusive	Result_uniqueEUR_sigma_AF_0_001 Exclusive	3.33e-01	2.24e-01	5.59e-02	8.29e-03
Result_uniqueEUR_sigma_AF_0_001 Exclusive	sigmaEA_WESR2_122 Exclusive	6.74e-02	2.62e-01	1.17e-02	4.69e-02
sigmaEA_WESR2_122 Exclusive	Overlap	5.92e-01	5.81e-01	2.19e-01	2.88e-01
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Overlap	6.22e-01	8.53e-01	4.30e-01	7.25e-01
Overlap	Exclusives	6.60e-01	6.87e-01	7.38e-02	5.37e-02



Evaluating how well sigmaEA_WESR2_122 genes are linked to Result_uniqueEUR_sigma_AF_0_001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigmaEA_WESR2_122 Exclusive	Result_uniqueEUR_sigma_AF_0_001	0.60	1.42	2.41	1.77	2.83
Result_uniqueEUR_sigma_AF_0_001 Exclusive	sigmaEA_WESR2_122	0.56	0.86	1.45	1.48	2.37
sigmaEA_WESR2_122 Exclusive	Result_uniqueEUR_sigma_AF_0_001 Exclusive	0.60	1.57	2.02	1.83	2.78
Result_uniqueEUR_sigma_AF_0_001 Exclusive	sigmaEA_WESR2_122 Exclusive	0.57	1.15	1.38	1.46	2.27
sigmaEA_WESR2_122 Exclusive	Overlap	0.60	0.26	0.94	1.06	1.31
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Overlap	0.54	-0.38	0.06	-0.01	0.68
Overlap	Exclusives	0.55	0.73	0.79	1.05	2.08

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigmaEA_WESR2_122 Exclusive	Result_uniqueEUR_sigma_AF_0_001	0.01	1.07	4.73	1.42	1.63
Result_uniqueEUR_sigma_AF_0_001 Exclusive	sigmaEA_WESR2_122	0.01	0.59	2.02	1.43	1.06
sigmaEA_WESR2_122 Exclusive	Result_uniqueEUR_sigma_AF_0_001 Exclusive	0.00	0.58	1.27	0.75	4.32
Result_uniqueEUR_sigma_AF_0_001 Exclusive	sigmaEA_WESR2_122 Exclusive	0.01	0.85	1.57	0.61	0.95
sigmaEA_WESR2_122 Exclusive	Overlap	0.00	3.63	5.27	6.12	5.32
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Overlap	0.00	1.24	1.37	0.92	1.32
Overlap	Exclusives	0.01	2.77	1.41	1.89	4.36

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigmaEA_WESR2_122 Exclusive	101	100	RFPL2
Result_uniqueEUR_sigma_AF_0_001 Exclusive	57	56	TMEM269
Overlap	21	21