Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_10 Exclusive	Result_uniqueEUR_sigma_AF_0_001	1.67e-01	1.87e-01	2.06e-02	1.03e-02
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Result_uniqueEUR_sigma_AF_001_10	1.24e-01	1.06e-01	9.13e-03	9.99e-02
Result_uniqueEUR_sigma_AF_001_10 Exclusive	Result_uniqueEUR_sigma_AF_0_001 Exclusive	1.88e-01	3.00e-01	2.85e-02	1.76e-02
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Result_uniqueEUR_sigma_AF_001_10 Exclusive	1.71e-01	2.05e-01	9.77e-03	8.72e-02
Result_uniqueEUR_sigma_AF_001_10 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	3.96e-02
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Overlap	1.98e-01	2.38e-01	7.92e-02	3.96e-02
Overlap	Exclusives	1.35e-02	5.81e-01	1.69e-01	2.78e-02



Evaluating how well Result_uniqueEUR_sigma_AF_001_10 genes are linked to Result_uniqueEUR_sigma_AF_0_001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_10 Exclusive	Result_uniqueEUR_sigma_AF_0_001	0.60	1.77	1.95	1.42	2.69
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Result_uniqueEUR_sigma_AF_001_10	0.56	1.06	1.39	1.37	2.53
Result_uniqueEUR_sigma_AF_001_10 Exclusive	Result_uniqueEUR_sigma_AF_0_001 Exclusive	0.59	1.63	1.90	1.23	2.64
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Result_uniqueEUR_sigma_AF_001_10 Exclusive	0.55	0.76	1.35	1.11	2.47
Result_uniqueEUR_sigma_AF_001_10 Exclusive	Overlap	0.99	1.75	1.98	2.22	1.67
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Overlap	0.97	1.26	1.66	1.72	1.76
Overlap	Exclusives	0.55	0.62	1.11	0.99	2.85

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_10 Exclusive	Result_uniqueEUR_sigma_AF_0_001	0.01	1.99	3.73	1.79	4.41
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Result_uniqueEUR_sigma_AF_001_10	0.01	1.84	2.09	2.40	2.09
Result_uniqueEUR_sigma_AF_001_10 Exclusive	Result_uniqueEUR_sigma_AF_0_001 Exclusive	0.01	1.90	2.51	1.60	1.68
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Result_uniqueEUR_sigma_AF_001_10 Exclusive	0.01	1.49	1.95	1.24	1.97
Result_uniqueEUR_sigma_AF_001_10 Exclusive	Overlap	0.00	17.66	31.52	11.32	5.33
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Overlap	0.00	1.60	0.89	1.11	3.61
Overlap	Exclusives	0.02	2.99	5.24	3.66	6.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Result_uniqueEUR_sigma_AF_001_10 Exclusive	139	137	RFPL2;AC245033.1
Result_uniqueEUR_sigma_AF_0_001 Exclusive	77	76	TMEM269
Overlap	1	1