Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Result_uniqueEUR_sigma_AF_0_001	Sigma_EA_WES_AF_01_1	1.78e-03	1.32e-02	1.23e-05	1.13e-03
Sigma_EA_WES_AF_01_1	Result_uniqueEUR_sigma_AF_0_001	1.01e-01	1.08e-02	1.15e-02	6.69e-04



Evaluating how well Result_uniqueEUR_sigma_AF_0_001 genes are linked to Sigma_EA_WES_AF_01_1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_0_001	Sigma_EA_WES_AF_01_1	0.59	3.44	3.29	3.19	3.28
Sigma_EA_WES_AF_01_1	Result_uniqueEUR_sigma_AF_0_001	0.62	2.10	3.99	2.50	3.56

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_0_001	Sigma_EA_WES_AF_01_1	0.01	6.36	4.14	4.49	4.85
Sigma_EA_WES_AF_01_1	Result_uniqueEUR_sigma_AF_0_001	0.01	2.23	7.35	2.32	8.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Result_uniqueEUR_sigma_AF_0_001	78	77	TMEM269
Sigma_EA_WES_AF_01_1	107	105	PRAMEF11;RFPL2