Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Result_uniqueEUR_sigma_AF_001_01	9.06e-01	8.77e-01	2.25e-01	7.90e-01
Result_uniqueEUR_sigma_AF_001_01 Exclusive	Result_uniqueEUR_sigma_AF_0_001	7.01e-01	5.51e-01	3.75e-01	1.76e-01
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Result_uniqueEUR_sigma_AF_001_01 Exclusive	9.66e-01	9.44e-01	2.63e-01	8.58e-01
Result_uniqueEUR_sigma_AF_001_01 Exclusive	Result_uniqueEUR_sigma_AF_0_001 Exclusive	7.76e-01	5.08e-01	4.06e-01	1.45e-01
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Overlap	3.96e-02	9.90e-02	3.96e-02	3.96e-02
Result_uniqueEUR_sigma_AF_001_01 Exclusive	Overlap	7.33e-01	9.70e-01	7.52e-01	9.70e-01
Overlap	Exclusives	6.02e-03	9.19e-01	5.58e-01	1.75e-01



Evaluating how well Result_uniqueEUR_sigma_AF_0_001 genes are linked to Result_uniqueEUR_sigma_AF_001_01 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Result_uniqueEUR_sigma_AF_001_01	0.53	-0.40	0.19	-0.53	0.97
Result_uniqueEUR_sigma_AF_001_01 Exclusive	Result_uniqueEUR_sigma_AF_0_001	0.54	0.02	-0.11	-0.21	1.33
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Result_uniqueEUR_sigma_AF_001_01 Exclusive	0.53	-0.43	-0.06	-0.49	0.87
Result_uniqueEUR_sigma_AF_001_01 Exclusive	Result_uniqueEUR_sigma_AF_0_001 Exclusive	0.54	0.14	-0.32	-0.30	1.32
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Overlap	0.97	1.58	2.03	1.81	1.73
Result_uniqueEUR_sigma_AF_001_01 Exclusive	Overlap	0.55	-0.40	-0.21	0.03	0.03
Overlap	Exclusives	0.55	-0.08	0.51	0.46	2.00

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Result_uniqueEUR_sigma_AF_001_01	0.01	-0.39	0.09	-0.33	0.62
Result_uniqueEUR_sigma_AF_001_01 Exclusive	Result_uniqueEUR_sigma_AF_0_001	0.00	-0.69	-0.13	-0.46	0.60
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Result_uniqueEUR_sigma_AF_001_01 Exclusive	0.01	-0.35	-0.21	-0.46	0.31
Result_uniqueEUR_sigma_AF_001_01 Exclusive	Result_uniqueEUR_sigma_AF_0_001 Exclusive	0.00	-0.49	-0.33	-0.71	0.78
Result_uniqueEUR_sigma_AF_0_001 Exclusive	Overlap	0.00	3.09	1.81	3.13	2.96
Result_uniqueEUR_sigma_AF_001_01 Exclusive	Overlap	0.00	-0.38	-0.26	-0.33	-0.23
Overlap	Exclusives	0.01	0.64	0.53	0.78	2.66

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Result_uniqueEUR_sigma_AF_0_001 Exclusive	77	76	TMEM269
Result_uniqueEUR_sigma_AF_001_01 Exclusive	102	101	AC245033.1
Overlap	1	1