Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_01 Exclusive	Sigma_EA_WES_AF_01_1	6.00e-02	1.78e-02	2.53e-03	2.07e-03
Sigma_EA_WES_AF_01_1 Exclusive	Result_uniqueEUR_sigma_AF_001_01	1.31e-01	1.69e-01	1.20e-01	1.09e-02
Result_uniqueEUR_sigma_AF_001_01 Exclusive	Sigma_EA_WES_AF_01_1 Exclusive	3.81e-02	7.63e-03	9.16e-04	4.80e-03
Sigma_EA_WES_AF_01_1 Exclusive	Result_uniqueEUR_sigma_AF_001_01 Exclusive	1.17e-01	2.86e-01	7.17e-02	3.40e-02
Result_uniqueEUR_sigma_AF_001_01 Exclusive	Overlap	7.14e-01	8.93e-01	4.70e-01	9.09e-03
Sigma_EA_WES_AF_01_1 Exclusive	Overlap	8.15e-01	5.79e-01	8.00e-01	6.07e-02
Overlap	Exclusives	1.99e-01	4.32e-01	7.87e-30	1.26e-02



Evaluating how well Result_uniqueEUR_sigma_AF_001_01 genes are linked to Sigma_EA_WES_AF_01_1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_01 Exclusive	Sigma_EA_WES_AF_01_1	0.59	2.69	2.92	2.42	3.23
Sigma_EA_WES_AF_01_1 Exclusive	Result_uniqueEUR_sigma_AF_001_01	0.59	2.38	2.13	1.76	3.31
Result_uniqueEUR_sigma_AF_001_01 Exclusive	Sigma_EA_WES_AF_01_1 Exclusive	0.57	2.08	2.74	2.61	3.36
Sigma_EA_WES_AF_01_1 Exclusive	Result_uniqueEUR_sigma_AF_001_01 Exclusive	0.58	2.62	1.91	1.97	2.99
Result_uniqueEUR_sigma_AF_001_01 Exclusive	Overlap	0.86	0.86	0.34	0.86	2.66
Sigma_EA_WES_AF_01_1 Exclusive	Overlap	0.83	0.32	0.08	0.57	2.36
Overlap	Exclusives	0.54	-0.98	1.15	1.20	2.23

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Result_uniqueEUR_sigma_AF_001_01 Exclusive	Sigma_EA_WES_AF_01_1	0.01	2.77	3.85	2.30	3.69
Sigma_EA_WES_AF_01_1 Exclusive	Result_uniqueEUR_sigma_AF_001_01	0.01	4.54	3.47	1.56	5.55
Result_uniqueEUR_sigma_AF_001_01 Exclusive	Sigma_EA_WES_AF_01_1 Exclusive	0.01	2.21	4.21	1.53	0.88
Sigma_EA_WES_AF_01_1 Exclusive	Result_uniqueEUR_sigma_AF_001_01 Exclusive	0.01	4.03	2.11	3.70	3.65
Result_uniqueEUR_sigma_AF_001_01 Exclusive	Overlap	0.00	0.04	-1.86	0.14	1.85
Sigma_EA_WES_AF_01_1 Exclusive	Overlap	0.00	5.78	16.46	7.32	16.66
Overlap	Exclusives	0.01	-0.29	1.37	1.14	1.38

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Result_uniqueEUR_sigma_AF_001_01 Exclusive	99	98	AC245033.1
Sigma_EA_WES_AF_01_1 Exclusive	104	102	RFPL2;PRAMEF11
Overlap	4	4