Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_WES_AF_0_001_1_78_140 Exclusive	tier2_gs	4.35e-01	9.36e-02	1.41e-02	1.16e-03
tier2_gs Exclusive	Sigma_EA_WES_AF_0_001_1_78_140	2.02e-01	1.58e-01	5.22e-05	2.27e-03
Sigma_EA_WES_AF_0_001_1_78_140 Exclusive	tier2_gs Exclusive	6.30e-01	1.49e-01	2.89e-02	4.74e-03
tier2_gs Exclusive	Sigma_EA_WES_AF_0_001_1_78_140 Exclusive	1.83e-01	1.63e-01	7.19e-05	3.89e-03
Sigma_EA_WES_AF_0_001_1_78_140 Exclusive	Overlap	2.97e-01	2.57e-01	7.92e-02	2.97e-01
tier2_gs Exclusive	Overlap	1.78e-01	4.75e-01	2.38e-01	3.96e-01
Overlap	Exclusives	5.87e-02	3.23e-02	1.34e-11	5.53e-06



Evaluating how well Sigma_EA_WES_AF_0_001_1_78_140 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_0_001_1_78_140 Exclusive	tier2_gs	0.69	2.00	3.06	2.43	4.33
tier2_gs Exclusive	Sigma_EA_WES_AF_0_001_1_78_140	0.57	2.00	2.05	2.11	4.04
Sigma_EA_WES_AF_0_001_1_78_140 Exclusive	tier2_gs Exclusive	0.68	1.26	2.38	2.11	4.42
tier2_gs Exclusive	Sigma_EA_WES_AF_0_001_1_78_140 Exclusive	0.57	2.09	1.70	2.05	3.95
Sigma_EA_WES_AF_0_001_1_78_140 Exclusive	Overlap	0.87	1.22	1.13	1.27	1.23
tier2_gs Exclusive	Overlap	0.84	1.47	0.88	1.10	1.20
Overlap	Exclusives	0.58	2.22	2.36	1.95	4.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_0_001_1_78_140 Exclusive	tier2_gs	0.01	4.28	12.67	7.92	19.35
tier2_gs Exclusive	Sigma_EA_WES_AF_0_001_1_78_140	0.02	5.27	5.67	4.41	7.59
Sigma_EA_WES_AF_0_001_1_78_140 Exclusive	tier2_gs Exclusive	0.01	3.12	11.42	7.38	16.55
tier2_gs Exclusive	Sigma_EA_WES_AF_0_001_1_78_140 Exclusive	0.02	6.80	5.17	6.04	8.69
Sigma_EA_WES_AF_0_001_1_78_140 Exclusive	Overlap	0.00	0.59	0.39	0.72	0.05
tier2_gs Exclusive	Overlap	0.00	0.51	-0.07	-0.08	0.02
Overlap	Exclusives	0.02	1.50	1.52	1.78	4.48

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_WES_AF_0_001_1_78_140 Exclusive	216	213	TMEM269;AC245033.1;RFPL2
tier2_gs Exclusive	45	42	TNSF13;IGH;TNSF12
Overlap	1	1