Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_WES_AF_0_001_1_78_140	Ismael_14_AD	2.45e-01	2.67e-01	5.24e-02	1.13e-03
Ismael_14_AD	Sigma_EA_WES_AF_0_001_1_78_140	3.85e-02	3.59e-01	4.23e-08	7.86e-03



Evaluating how well Sigma_EA_WES_AF_0_001_1_78_140 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_0_001_1_78_140	Ismael_14_AD	0.77	0.69	1.38	1.23	3.35
Ismael_14_AD	Sigma_EA_WES_AF_0_001_1_78_140	0.56	2.66	1.59	1.41	3.05

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_WES_AF_0_001_1_78_140	Ismael_14_AD	0.01	2.38	6.62	2.42	0.76
Ismael_14_AD	Sigma_EA_WES_AF_0_001_1_78_140	0.01	2.78	1.57	2.10	2.23

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_WES_AF_0_001_1_78_140	217	214	AC245033.1;RFPL2;TMEM269
Ismael_14_AD	14	14