Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) Feixiong_448 Exclusive UKB_AD 3.23e-02 3.91e-01 1.82e-02 7.63e-02 UKB_AD Exclusive Feixiong_448 2.31e-01 2.67e-01 2.18e-03 6.03e-02 Feixiong_448 Exclusive UKB_AD Exclusive 1.33e-02 6.59e-01 7.10e-02 7.08e-01 UKB_AD Exclusive Feixiong_448 Exclusive 4.66e-01 2.43e-01 2.60e-03 5.24e-02 Feixiong_448 Exclusive Overlap 4.32e-06 1.55e-04 1.08e-06 8.28e-09 UKB_AD Exclusive Overlap 5.95e-02 5.60e-01 5.95e-02 1.20e-02 Overlap Exclusives 1.33e-04 8.83e-11 1.43e-46 2.05e-13 Evaluating how well Feixiong_448 genes are linked to UKB_AD genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Feixiong_448 Exclusive UKB_AD 0.56 0.56 0.51 0.71 1.99 UKB_AD Exclusive Feixiong_448 0.54 1.07 1.66 1.63 2.78 Feixiong_448 Exclusive UKB_AD Exclusive 0.52 -1.03 -0.80 -0.69 0.78 UKB_AD Exclusive Feixiong_448 Exclusive 0.53 0.72 1.31 1.06 2.56 Feixiong_448 Exclusive Overlap 0.97 5.52 5.68 5.14 4.82 UKB_AD Exclusive Overlap 0.74 1.96 1.08 1.69 2.93 Overlap Exclusives 0.62 4.78 10.80 5.01 8.95 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Feixiong_448 Exclusive UKB_AD 0.02 25.85 19.66 26.65 20.02 UKB_AD Exclusive Feixiong_448 0.02 1.27 1.51 1.69 2.61 Feixiong_448 Exclusive UKB_AD Exclusive 0.01 4.50 2.77 4.27 2.50 UKB_AD Exclusive Feixiong_448 Exclusive 0.02 0.82 1.51 1.11 1.92 Feixiong_448 Exclusive Overlap 0.06 130.18 52.55 147.39 193.19 UKB_AD Exclusive Overlap 0.00 1.32 -0.43 1.45 0.71 Overlap Exclusives 0.08 19.56 50.36 22.45 41.25 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes Feixiong_448 Exclusive 439 419 ATP6V1G2-DDX39B;IGHV3-66;IGHV3-74;IGHV4-61;IGHV3-64;APOC4-APOC2;IGHG2;OR2J1;IGHV1-69;IGHV1-58;IGHV2-70;C17orf107;TRIM39-RPP21;IGHV3-73;IGHG3;IGHG1;IGHV3-53;IGHA1;IGHV3-72;IGHV4-59 UKB_AD Exclusive 92 92 Overlap 9 9