Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Feixiong_448 Exclusive	UKB_ADProxy	5.36e-02	1.49e-01	1.67e-02	2.44e-03
UKB_ADProxy Exclusive	Feixiong_448	8.07e-02	2.06e-01	2.62e-05	1.83e-02
Feixiong_448 Exclusive	UKB_ADProxy Exclusive	7.01e-01	5.57e-01	5.56e-01	4.91e-02
UKB_ADProxy Exclusive	Feixiong_448 Exclusive	6.69e-02	2.71e-01	3.87e-05	1.83e-02
Feixiong_448 Exclusive	Overlap	3.52e-06	1.38e-04	2.00e-06	2.00e-06
UKB_ADProxy Exclusive	Overlap	1.00e+00	7.94e-01	9.47e-01	9.08e-01
Overlap	Exclusives	3.24e-06	1.81e-12	5.07e-20	1.82e-13



Evaluating how well Feixiong_448 genes are linked to UKB_ADProxy genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Feixiong_448 Exclusive	UKB_ADProxy	0.61	2.53	2.58	2.60	3.73
UKB_ADProxy Exclusive	Feixiong_448	0.54	1.94	1.82	1.76	3.08
Feixiong_448 Exclusive	UKB_ADProxy Exclusive	0.57	0.36	0.90	0.48	2.37
UKB_ADProxy Exclusive	Feixiong_448 Exclusive	0.54	2.36	1.87	1.79	3.06
Feixiong_448 Exclusive	Overlap	0.88	6.10	6.56	5.47	3.90
UKB_ADProxy Exclusive	Overlap	0.56	0.17	-0.32	0.13	0.68
Overlap	Exclusives	0.63	6.44	11.32	5.76	10.50

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Feixiong_448 Exclusive	UKB_ADProxy	0.04	63.32	55.06	26.85	56.86
UKB_ADProxy Exclusive	Feixiong_448	0.02	1.35	0.91	1.35	2.05
Feixiong_448 Exclusive	UKB_ADProxy Exclusive	0.01	2.05	3.57	2.08	3.59
UKB_ADProxy Exclusive	Feixiong_448 Exclusive	0.02	1.62	1.27	1.43	2.05
Feixiong_448 Exclusive	Overlap	0.20	421.29	207.83	16.48	381.16
UKB_ADProxy Exclusive	Overlap	0.00	-0.46	-0.68	-0.13	-0.16
Overlap	Exclusives	0.08	28.34	60.90	28.00	51.94

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Feixiong_448 Exclusive	436	416	TRIM39-RPP21;IGHG3;ATP6V1G2-DDX39B;APOC4-APOC2;IGHV2-70;IGHG1;C17orf107;IGHV3-64;IGHV3-72;IGHV3-53;IGHG2;IGHV4-59;OR2J1;IGHV1-58;IGHV4-61;IGHV3-66;IGHV3-74;IGHV1-69;IGHA1;IGHV3-73
UKB_ADProxy Exclusive	83	80	TMEM265;KDM5D;SERPINA3
Overlap	12	12