Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Feixiong_448 Exclusive	UKB_VD	1.92e-01	3.29e-01	3.82e-01	3.83e-01
UKB_VD Exclusive	Feixiong_448	1.06e-02	5.69e-02	2.40e-02	2.87e-01
Feixiong_448 Exclusive	UKB_VD Exclusive	4.53e-02	7.60e-02	2.12e-01	2.29e-01
UKB_VD Exclusive	Feixiong_448 Exclusive	1.15e-02	7.34e-02	4.03e-02	2.34e-01
Feixiong_448 Exclusive	Overlap	3.26e-08	7.20e-04	9.39e-10	3.44e-09
UKB_VD Exclusive	Overlap	6.09e-01	8.12e-01	6.25e-01	3.16e-01
Overlap	Exclusives	4.45e-08	3.61e-11	5.38e-47	2.59e-13



Evaluating how well Feixiong_448 genes are linked to UKB_VD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Feixiong_448 Exclusive	UKB_VD	0.51	-0.17	-0.88	-0.33	0.56
UKB_VD Exclusive	Feixiong_448	0.49	-1.33	-3.06	-1.31	-0.96
Feixiong_448 Exclusive	UKB_VD Exclusive	0.48	-1.24	-1.69	-1.02	-0.77
UKB_VD Exclusive	Feixiong_448 Exclusive	0.49	-1.28	-2.99	-1.17	-1.02
Feixiong_448 Exclusive	Overlap	0.99	3.69	3.79	3.34	4.48
UKB_VD Exclusive	Overlap	0.57	-0.49	-0.55	-0.62	0.53
Overlap	Exclusives	0.62	6.77	10.92	4.39	9.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Feixiong_448 Exclusive	UKB_VD	0.01	20.53	3.38	16.25	12.51
UKB_VD Exclusive	Feixiong_448	0.02	-1.29	-2.43	-1.04	-1.48
Feixiong_448 Exclusive	UKB_VD Exclusive	0.00	-1.88	-0.48	-1.55	-1.02
UKB_VD Exclusive	Feixiong_448 Exclusive	0.02	-1.29	-2.46	-1.03	-1.53
Feixiong_448 Exclusive	Overlap	0.09	153.45	142.03	172.77	301.46
UKB_VD Exclusive	Overlap	0.00	-0.64	-0.21	-0.64	-0.30
Overlap	Exclusives	0.08	28.28	60.45	20.27	51.31

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Feixiong_448 Exclusive	443	423	C17orf107;IGHV3-64;IGHV1-58;IGHV3-66;IGHV4-59;IGHV3-73;IGHV1-69;OR2J1;IGHG3;IGHV2-70;IGHG1;ATP6V1G2-DDX39B;IGHV4-61;IGHV3-53;TRIM39-RPP21;APOC4-APOC2;IGHG2;IGHA1;IGHV3-72;IGHV3-74
UKB_VD Exclusive	70	69	AL031777.3
Overlap	5	5