Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Feixiong_448 Exclusive	UKB_UD	2.16e-01	6.86e-01	1.66e-01	1.27e-01
UKB_UD Exclusive	Feixiong_448	2.45e-02	2.90e-02	1.19e-04	1.67e-03
Feixiong_448 Exclusive	UKB_UD Exclusive	4.43e-01	7.59e-01	5.03e-01	2.79e-01
UKB_UD Exclusive	Feixiong_448 Exclusive	2.81e-02	2.32e-02	6.73e-04	3.18e-03
Feixiong_448 Exclusive	Overlap	8.41e-03	8.41e-03	8.41e-03	7.47e-03
UKB_UD Exclusive	Overlap	4.23e-01	5.79e-01	3.48e-01	1.62e-01
Overlap	Exclusives	1.61e-07	6.78e-14	4.08e-62	1.84e-17



Evaluating how well Feixiong_448 genes are linked to UKB_UD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Feixiong_448 Exclusive	UKB_UD	0.56	1.30	1.04	1.55	1.91
UKB_UD Exclusive	Feixiong_448	0.55	1.73	2.21	2.02	3.41
Feixiong_448 Exclusive	UKB_UD Exclusive	0.54	0.61	0.51	0.63	1.02
UKB_UD Exclusive	Feixiong_448 Exclusive	0.54	1.58	2.53	1.62	3.14
Feixiong_448 Exclusive	Overlap	0.94	3.18	2.06	3.10	3.07
UKB_UD Exclusive	Overlap	0.77	1.46	1.11	1.24	1.86
Overlap	Exclusives	0.63	6.08	12.17	4.30	10.45

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Feixiong_448 Exclusive	UKB_UD	0.01	26.43	15.60	27.30	6.98
UKB_UD Exclusive	Feixiong_448	0.03	1.30	1.80	1.80	3.01
Feixiong_448 Exclusive	UKB_UD Exclusive	0.01	3.83	1.61	2.60	0.67
UKB_UD Exclusive	Feixiong_448 Exclusive	0.02	1.32	2.47	1.24	2.26
Feixiong_448 Exclusive	Overlap	0.09	137.03	143.45	159.24	114.37
UKB_UD Exclusive	Overlap	0.00	0.75	0.65	2.16	3.43
Overlap	Exclusives	0.09	31.07	59.81	23.33	52.78

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Feixiong_448 Exclusive	444	424	IGHG2;IGHV1-58;OR2J1;TRIM39-RPP21;IGHV3-72;IGHV1-69;IGHG1;IGHV3-73;IGHV4-59;IGHG3;IGHV3-66;IGHV3-74;APOC4-APOC2;IGHV3-64;IGHV4-61;IGHV2-70;C17orf107;IGHA1;ATP6V1G2-DDX39B;IGHV3-53
UKB_UD Exclusive	79	78	C11orf97
Overlap	4	4