Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Feixiong_448 Exclusive	UKB_FTD	5.49e-01	5.46e-01	4.55e-01	8.45e-01
UKB_FTD Exclusive	Feixiong_448	1.72e-01	9.90e-02	2.33e-01	3.12e-01
Feixiong_448 Exclusive	UKB_FTD Exclusive	3.42e-01	6.12e-01	5.12e-01	9.80e-01
UKB_FTD Exclusive	Feixiong_448 Exclusive	1.67e-01	2.30e-01	2.36e-01	2.63e-01
Feixiong_448 Exclusive	Overlap	3.07e-01	1.13e-01	1.58e-01	5.71e-02
UKB_FTD Exclusive	Overlap	2.76e-01	3.92e-01	2.58e-01	6.22e-01
Overlap	Exclusives	1.02e-01	3.64e-01	6.30e-03	4.12e-02



Evaluating how well Feixiong_448 genes are linked to UKB_FTD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Feixiong_448 Exclusive	UKB_FTD	0.52	0.58	0.53	0.67	0.56
UKB_FTD Exclusive	Feixiong_448	0.51	-0.08	-0.86	0.09	1.09
Feixiong_448 Exclusive	UKB_FTD Exclusive	0.50	0.15	-0.03	0.03	0.07
UKB_FTD Exclusive	Feixiong_448 Exclusive	0.51	-0.09	-0.48	0.12	1.32
Feixiong_448 Exclusive	Overlap	0.72	2.05	1.48	2.07	1.79
UKB_FTD Exclusive	Overlap	0.43	-1.15	-0.90	-0.95	-0.35
Overlap	Exclusives	0.54	0.10	1.86	0.64	3.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Feixiong_448 Exclusive	UKB_FTD	0.00	0.90	0.71	0.93	0.15
UKB_FTD Exclusive	Feixiong_448	0.02	0.06	-0.43	0.16	0.33
Feixiong_448 Exclusive	UKB_FTD Exclusive	0.00	0.58	0.27	0.30	-0.14
UKB_FTD Exclusive	Feixiong_448 Exclusive	0.02	0.04	-0.25	0.14	0.63
Feixiong_448 Exclusive	Overlap	0.00	5.41	0.84	5.77	0.18
UKB_FTD Exclusive	Overlap	0.00	-0.71	-0.61	-0.70	-0.11
Overlap	Exclusives	0.03	1.31	5.07	1.81	6.54

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Feixiong_448 Exclusive	444	424	IGHV4-61;OR2J1;IGHG3;IGHV1-58;IGHV3-73;APOC4-APOC2;IGHV3-64;IGHA1;IGHV3-53;TRIM39-RPP21;IGHV4-59;IGHG1;IGHV2-70;ATP6V1G2-DDX39B;IGHG2;IGHV1-69;IGHV3-74;IGHV3-66;C17orf107;IGHV3-72
UKB_FTD Exclusive	59	58	AC018554.3
Overlap	4	4